Başlık için Makale Koleksiyonu listeleme
Toplam kayıt 295, listelenen: 242-261
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Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan (TM)) platform
(Elsevier Science, 2017)Vascular invasion is a pathological hallmark of hepatocellular carcinoma (HCC), associated With poor prognosis; it is strongly related to the early recurrence and poor survival after curative resection. In order to determine ... -
Proteomics analysis of CA1 region of the hippocampus in pre-, progression and pathological stages in a mouse model of the alzheimer’s disease
(Bentham Science Publishers, 2019)Background: CA1 subregion of the hippocampal formation is one of the primarily affected structures in AD, yet not much is known about proteome alterations in the extracellular milieu of this region. Objective: In this ... -
Prunus spinosa L. meyvelerinin deneysel yara iyileşmesi üzerine etkileri
(2017)Farelerde oluşturduğumuz deneysel yara modellerinde, Prunus Spinosa L. metanollü meyve ekstresini kullanarak, bu ekstrenin yara iyileşmesindeki etkisini araştırdık. Otuz iki adet C57/Black fare ile 4 deney grubu oluşturuldu. ... -
Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method
(Lippincott Williams & Wilkins, 2021)Background Quantitative analysis of the high-resolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are ... -
Quercetin enhances human sperm motility in a dose and time dependent manner
(Istanbul Medipol University, 2020)The aim of this study was to investigate the effect of quercetin on the motility of ejaculated human spermatozoa in asthenozoospermic cases by using different doses and exposure times. Semen samples of 94 men were incubated ... -
Recombinant plasmid-based quantitative Real-Time PCR analysis of salmonella enterica serotypes and its application to milk samples
(Elsevier Science Bv, 2016)The aim of the current study was to develop, a new, rapid, sensitive and quantitative Salmonella detection method using a Real-Time PCR technique based on an inexpensive, easy to produce, convenient and standardized ... -
Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study
(Oxford University Press Inc, 2022)In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors ... -
Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment
(IOS Press, 2021)Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha ... -
Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia
(Elsevier, 2020)Extending Basar's theory of event-related EEG oscillations, here we hypothesize that even in quiet wakefulness, transient increases in delta rhythms may enhance global cortical arousal as revealed by the desynchronization ... -
Resting-state fMRI analysis in apathetic Alzheimer's disease
(AVES, 2020)PURPOSEDiagnosis of comorbid psychiatric conditions are a significant determinant for the prognosis of neurodegenerative diseases. Apathy, which is a behavioral executive dysfunction, frequently accompanies Alzheimer's ... -
The rhythmicity of life: A review of the circadian clocks
(Begell House Inc., 2021)Physiology of the mammalian body has been adapted to diurnal cycles of around 24 h, an evolutionary situation that affects a wide spectrum of biological events including sleep-to-wake transitions, feeding/fasting, body ... -
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish
(Taylor & Francis Ltd, 2022)Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and ... -
The role of circadian rhythm in the regulation of cellular protein profiles in the brain
(The Scientific and Technological Research Council of Turkey, 2021)Background/aim: Circadian rhythm plays a significant role in the regulation of almost all kinds of physiological processes. In addition, it may also have a direct or indirect effect on the neurodegenerative processes, ... -
Role of erythropoietin and its receptor in the development of endometriosis in rats
(Galenos Yayıncılık, 2019)Objective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial ... -
Skov-3 over kanseri hücre hattında fotodinamik terapi uygulaması
(2017)Sürdürülen sayısız araştırmaya ve geliştirilen ilaçlara rağmen günümüzde kanser hala milyonlarca insanın ölümüne neden olan hastalıkların başında gelmektedir. Over kanseri en ölümcül kanserlerden biri olup kadınlarda en ... -
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
(Elife Sciences Publications Ltd, 2019)Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often ... -
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
(Tubitak Scientific & Technical Research Council Turkey, 2019)The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ... -
Stratification of the gut microbiota composition landscape across the alzheimer's disease continuum in a Turkish cohort
(American Society for Microbiology, 2022)Alzheimer's disease (AD) is a heterogeneous disorder that spans a continuum with multiple phases, including preclinical, mild cognitive impairment, and dementia. Unlike for most other chronic diseases, human studies reporting ... -
Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy
(Turkey Clinics, 2022)Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the ... -
Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
(NLM (Medline), 2022)Inflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the brain thus promoting tissue damage after stroke. However, the ...
