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A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms
(Nature Research, 2021)Cerebral cavernous malformation (CCM) is a vascular lesion of the central nervous system that may lead to distinct symptoms among patients including cerebral hemorrhages, epileptic seizures, focal neurologic deficits, ... -
Novel synthetic approaches for bisnaphthalimidopropyl (BNIP) derivatives as potential anti-parasitic agents for the treatment of leishmaniasis
(MDPI, 2019)Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, ... -
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
(Frontiers Media S.A., 2022)Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ... -
Predicting the effects of repetitive transcranial magnetic stimulation on cognitive functions in patients with alzheimer's disease by automated EEG analysis
(Frontiers Media SA, 2022)Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder that generally affects the elderly. Today, after the limited benefit of the pharmacological treatment strategies, numerous noninvasive brain ... -
Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
(Nature Publishing Group, 2019)Although clinically apparent metastasis is associated with late stages of cancer development, micro-metastatic dissemination may be an early event. However, the fate of these early disseminated tumor cells (DTC) remains ... -
Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
(Elsevier, 2020)The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein ... -
Proteomic analysis of kidney preservation solutions prior to renal transplantation
(Public Library Science, 2016)One of the main issues in kidney transplantation is the optimal functional preservation of the organ until its transplantation into the appropriate recipient. Despite intensive efforts, the functional preservation period ... -
The role of circadian rhythm in the regulation of cellular protein profiles in the brain
(The Scientific and Technological Research Council of Turkey, 2021)Background/aim: Circadian rhythm plays a significant role in the regulation of almost all kinds of physiological processes. In addition, it may also have a direct or indirect effect on the neurodegenerative processes, ... -
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
(Elife Sciences Publications Ltd, 2019)Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often ... -
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
(Tubitak Scientific & Technical Research Council Turkey, 2019)The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ... -
Stratification of the gut microbiota composition landscape across the alzheimer's disease continuum in a Turkish cohort
(American Society for Microbiology, 2022)Alzheimer's disease (AD) is a heterogeneous disorder that spans a continuum with multiple phases, including preclinical, mild cognitive impairment, and dementia. Unlike for most other chronic diseases, human studies reporting ... -
Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy
(Turkey Clinics, 2022)Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the ... -
Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
(NLM (Medline), 2022)Inflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the brain thus promoting tissue damage after stroke. However, the ... -
Therapeutic role of repetitive transcranial magnetic stimulation in Alzheimer's and Parkinson's disease: Electroencephalography microstate correlates
(Frontiers Media SA, 2022)Introduction: The microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation ... -
TIM-3/Gal-9 interaction affects glucose and lipid metabolism in acute myeloid leukemia cell lines
(Frontiers Media SA, 2023)Introduction: T-cell immunoglobulin and mucin domain-3 (TIM-3) is a transmembrane molecule first identified as an immunoregulator. This molecule is also expressed on leukemic cells in acute myeloid leukemia and master cell ... -
TIM-3/Galectin-9 interaction and glutamine metabolism in AML cell lines, HL-60 and THP-1
(BioMed Central Ltd, 2024)Background: T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a cell surface molecule that was first discovered on T cells. However, recent studies revealed that it is also highly expressed in acute myeloid ... -
Transfer and integration of breast milk stem cells to the brain of suckling pups
(Nature Publishing Group, 2018)Beside its unique nutritional content breast milk also contains live cells from the mother. Fate of these cells in the offspring has not been adequately described. In this study, we aimed to detect and identify maternal ... -
Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model
(Scientific and Technological Research Council of Turkey (TÜBİTAK), 2020)Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, ...