ORCID "0000-0001-6494-8923" Makale Koleksiyonu için listeleme
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Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
Beuker, Carolin; Schafflick, David; Strecker, Jan-Kolja; Heming, Michael; Li, Xiaolin; Wolbert, Jolien; Schmidt-Pogoda, Antje; Thomas, Christian; Kuhlmann, Tanja; Aranda-Pardos, Irene; A-Gonzalez, Noelia; Kumar, Praveen Ashok; Werner, Yves; Kılıç, Ertuğrul; Hermann, Dirk M.; Wiendl, Heinz; Stumm, Ralf; zu Hörste, Gerd Meyer; Minnerup, Jens (NLM (Medline), 2022)Inflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the brain thus promoting tissue damage after stroke. However, the ... -
Sustained neurological recovery induced by resveratrol is associated with angioneurogenesis rather than neuroprotection after focal cerebral ischemia
Hermann, Dirk Matthias; Zechariah, Anil; Kaltwasser, Britta; Bosche, Bert; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Doeppner, Thorsten Roland (Academic Press, 2015)According to the French paradox, red wine consumption reduces the incidence of vascular diseases even in the presence of highly saturated fatty acid intake. This phenomenon is widely attributed to the phytoalexin resveratrol, ... -
Systemic proteasome inhibition induces sustained post-stroke neurological recovery and neuroprotection via mechanisms involving reversal of peripheral immunosuppression and preservation of blood-brain-barrier integrity
Doeppner, Thorsten Roland; Kaltwasser, Britta; Kuckelkorn, Ulrike; Henkelein, Petra; Bretschneider, Eva; Kılıç, Ertuğrul; Hermann, Dirk M. (Springer, 2016)In view of its profound effect on cell survival and function, the modulation of the ubiquitin-proteasome-system has recently been shown to promote neurological recovery and brain remodeling after focal cerebral ischemia. ... -
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine
Keleştemur, Taha; Yuluğ, Burak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kılıç, Ülkan; Çağlayan, Berrak; Yalçın, Esra; Gündoğdu, Reyhan Zeynep; Kılıç, Ertuğrul (Elsevier Ireland Ltd, 2016)The tissue damage that emerges during traumatic brain injury (TBI) is a consequence of a variety of pathophysiological events, including free radical generation and over-activation of N-methyl-D-aspartate-type glutamate ... -
Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3
Kartal, Ömer; Aydınöz, Seçil; Kartal, Ayşe Tuğba; Keleştemur, Taha; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Karademir, Ferhan; Süleymanoğlu, Selami; Kul, Mustafa; Yuluğ, Burak; Kılıç, Ertuğrul (Springer/Plenum Publishers, 2016)Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental ... -
Time-of-day dependent neuronal injury after ischemic stroke: Implication of circadian clock transcriptional factor bmal1 and survival kinase akt
Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Ahmet Burak; Türkseven, Şeyma; Gürel, Büşra; Keleştemur, Taha; Sertel, Elif; Şahin, Zafer; Kutlu, Selim; Kılıç, Ülkan; Baykal, Ahmet Tarık; Kılıç, Ertuğrul (Humana Press Inc, 2018)Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained ... -
Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model
Ozansoy, Mehmet; Altıntaş, Mehmet Özgen; Ozansoy, Muzaffer Beyza; Günay, Necmeddin; Kılıç, Ertuğrul; Kılıç, Ülkan (Scientific and Technological Research Council of Turkey (TÜBİTAK), 2020)Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, ... -
The unconventional growth factors cerebral dopamine neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor promote post-ischemic neurological recovery, perilesional brain remodeling, and lesion-remote axonal plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Sertel Evren, Elif; Çağlayan, Berrak; Kılıç, Ülkan; Ateş, Nilay; Çağlayan, Aysun; Daşdelen, Muhammed Furkan; Doeppner, Thorsten Roland; Saarma, Mart; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Springer, 2023)Considerable efforts are currently made to develop strategies that boost endogenous recovery once a stroke has occurred. Owing to their restorative properties, neurotrophic factors are attractive candidates that capitalize ...