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Synthesis and Biological Applications of Quantum Dots
(Springer International Publishing Ag, 2016)One of the fastest moving fields in nanotechnology is the application of quantum dots (QDs) in biology. These light-emitting materials are a new class of fluorescent labels in biomedical field. The superior properties such ... -
Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines
(Academic Press Inc Elsevier Science, 2019)Warburg hypothesized that the energy consumption of cancer cells is different than the normal cells. When compared to normal conditions, cancer cells do not undergo tricarboxylic acid (TCA) cycle therefore resulting in ... -
Synthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acy1-2,3-dihydropyridones
(Pergamon-Elsevier Science, 2015)We describe herein a general and efficient synthetic approach toward substituted pyridines from functionalized N-acy1-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative ... -
Systemic proteasome inhibition induces sustained post-stroke neurological recovery and neuroprotection via mechanisms involving reversal of peripheral immunosuppression and preservation of blood-brain-barrier integrity
(Springer, 2016)In view of its profound effect on cell survival and function, the modulation of the ubiquitin-proteasome-system has recently been shown to promote neurological recovery and brain remodeling after focal cerebral ischemia. ... -
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine
(Elsevier Ireland Ltd, 2016)The tissue damage that emerges during traumatic brain injury (TBI) is a consequence of a variety of pathophysiological events, including free radical generation and over-activation of N-methyl-D-aspartate-type glutamate ... -
Therapeutic effects of metformin for noise induced hearing loss
(W.B. Saunders, 2020)Objective: This study aimed to investigate the healing effect of metformin on noise induced hearing loss (NIHL) by measuring audiological, biochemical and histological parameters.Materials and methods: 32 rats were divided ... -
Therapeutic role of repetitive transcranial magnetic stimulation in Alzheimer's and Parkinson's disease: Electroencephalography microstate correlates
(Frontiers Media SA, 2022)Introduction: The microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation ... -
Theta and alpha oscillatory responses differentiate between six-to seven-year-old children and adults during successful visual and auditory memory encoding
(Elsevier, 2020)The healthy maturation of the brain is one of the intriguing topics that need to be investigated to understand human brain and child development. The present study aimed to investigate the development of memory processes ... -
Tilia tomentosa moench çiçeklerinin uçucu bileşenlerinin ve çeşitli in vitro biyolojik aktivitelerinin incelenmesi
(2019)Amaç: Tilia tomentosa Moench. (Malvaceae) bitkisinin çiçeklerinden elde edilen n-hekzan ekstresinin uçucu bileşenleri, toplam fenolik madde miktarı, in vitro antioksidan, antimikrobiyal ve hücre canlılığı aktivitelerinin ... -
TIM-3/Gal-9 interaction affects glucose and lipid metabolism in acute myeloid leukemia cell lines
(Frontiers Media SA, 2023)Introduction: T-cell immunoglobulin and mucin domain-3 (TIM-3) is a transmembrane molecule first identified as an immunoregulator. This molecule is also expressed on leukemic cells in acute myeloid leukemia and master cell ... -
TIM-3/Galectin-9 interaction and glutamine metabolism in AML cell lines, HL-60 and THP-1
(BioMed Central Ltd, 2024)Background: T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a cell surface molecule that was first discovered on T cells. However, recent studies revealed that it is also highly expressed in acute myeloid ... -
Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3
(Springer/Plenum Publishers, 2016)Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental ... -
Time irreversibility of resting-state activity in the healthy brain and pathology
(Frontiers Media S.A., 2020)Characterizing brain activity at rest is of paramount importance to our understanding both of general principles of brain functioning and of the way brain dynamics is affected in the presence of neurological or psychiatric ... -
Time-of-day dependent neuronal injury after ischemic stroke: Implication of circadian clock transcriptional factor bmal1 and survival kinase akt
(Humana Press Inc, 2018)Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained ... -
Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
(Elsevier Ltd, 2021)Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ... -
Transfer and integration of breast milk stem cells to the brain of suckling pups
(Nature Publishing Group, 2018)Beside its unique nutritional content breast milk also contains live cells from the mother. Fate of these cells in the offspring has not been adequately described. In this study, we aimed to detect and identify maternal ... -
Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease
(Elsevier B.V., 2022)Alzheimer's disease dementia (ADD) is the most diffuse neurodegenerative disorder belonging to mild cognitive impairment (MCI) and dementia in old persons. This disease is provoked by an abnormal accumulation of amyloid-beta ... -
Türkiye popülasyonunda HLA-DQ polimorfizmlerinin Hepatit B virüs enfeksiyonu ile ilişkisi
(İstanbul Üniversitesi, 2022)Amaç Konak genetik faktörleri hepatit B virüs (HBV) enfeksiyonunun doğal seyri ve HBV ilişkili karaciğer hastalıklarının gelişme riski ile progresyonu üzerinde etkili olabilmektedir. Bu çalışmada HLA-DQ gen rs9272105, ... -
TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice
(Elsevier Inc., 2023)Cryptochromes (CRYs), transcriptional repressors of the circadian clock in mammals, inhibit cAMP production when glucagon activates G-protein coupled receptors. Therefore, molecules that modulate CRYs have the potential ... -
Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model
(Scientific and Technological Research Council of Turkey (TÜBİTAK), 2020)Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, ...
