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Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Günal, Mehmet Yalçın; Çağlayan, Berrak; Yalçın, Esra; Keleştemur, Taha; Gündoğdu, Reyhan Zeynep; Yuluğ, Burak; Yılmaz, Bayram; Kerman, Bilal Ersen; Kılıç, Ertuğrul (Elsevier Sciences Bv, 2017)Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ... -
Power spectral density and coherence analysis of eye disease with and without visual hallucination
Yıldız, Sultan; Yuluğ, Burak; Kocabora, Mehmet Selim; Hanoğlu, Lütfü (Elsevier Ireland Ltd, 2021)Objectives: Charles Bonnet Syndrome (CBS) is a rare clinical condition which has been defined as complex visual hallucinations (CVH) due to visual loss. This study investigated differences in the EEG power spectral density ... -
Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method
Avnioğlu, Seda; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak (Lippincott Williams & Wilkins, 2021)Background Quantitative analysis of the high-resolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are ... -
A structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients
Velioğlu, Halil Aziz; Ayyıldız, Behçet; Ayyıldız, Sevilay; Sütçübaşı, Bernis; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Yuluğ, Burak (John Wiley and Sons Inc, 2023)In Alzheimer's disease (AD), structural and functional changes in the brain may give rise to disruption of specific cognitive functions. The aim of this study is to investigate the functional connectivity alterations in ... -
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine
Keleştemur, Taha; Yuluğ, Burak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kılıç, Ülkan; Çağlayan, Berrak; Yalçın, Esra; Gündoğdu, Reyhan Zeynep; Kılıç, Ertuğrul (Elsevier Ireland Ltd, 2016)The tissue damage that emerges during traumatic brain injury (TBI) is a consequence of a variety of pathophysiological events, including free radical generation and over-activation of N-methyl-D-aspartate-type glutamate ... -
Therapeutic role of repetitive transcranial magnetic stimulation in Alzheimer's and Parkinson's disease: Electroencephalography microstate correlates
Hanoğlu, Lütfü; Toplutaş, Eren; Sarıçaoğlu, Mevhibe; Velioğlu, Halil Aziz; Yıldız, Sultan; Yuluğ, Burak (Frontiers Media SA, 2022)Introduction: The microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation ... -
Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3
Kartal, Ömer; Aydınöz, Seçil; Kartal, Ayşe Tuğba; Keleştemur, Taha; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Karademir, Ferhan; Süleymanoğlu, Selami; Kul, Mustafa; Yuluğ, Burak; Kılıç, Ertuğrul (Springer/Plenum Publishers, 2016)Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental ... -
Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Özdemir Öktem, Ece; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfü; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, Burak (Elsevier Ltd, 2021)Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ...