Ara
Toplam kayıt 251, listelenen: 131-140
Early stage alterations in CA1 extracellular region proteins indicate dysregulation of IL6 and iron homeostasis in the 5XFAD Alzheimer's disease mouse model
(Ios Press, 2018)
In recent years, an increasing number of research papers revealed that the compositional and volumetric alterations in the extracellular matrix are the consequences of aging and may be related to Alzheimer's disease (AD). ...
ABCG5 and ABCG8 gene polymorphisms in type 2 diabetes mellitus in the Turkish population
(Elsevier, 2015)
Objective: The aim of the present study was to investigate the relationship between ABCG5 and ABCG8 gene polymorphisms and plasma lipid concentrations in Turkish patients with type 2 diabetes mellitus. Methods: Included ...
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
(Tubitak Scientific & Technical Research Council Turkey, 2019)
The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ...
Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774
(Tubitak Scientific & Technical Research Council Turkey, 2018)
Background/aim: In this study, the effects of resveratrol as a natural polyphenol compound, gemcitabine as an antimetabolite that has nucleoside structure analogous to deoxycytidine, and para-aminophenol-derived paracetamol ...
Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy
(Turkey Clinics, 2022)
Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the ...
Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
(Elsevier Ltd, 2021)
Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ...
Effects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing
(Taylor and Francis Ltd, 2017)
We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and ...
Neuroprotective effects of curcumin-loaded emulsomes in a laser axotomy-induced CNS injury model
(Dove Medical Press Ltd, 2020)
Purpose: Curcumin, a polyphenol isolated from the rhizomes of turmeric, holds great potential as a neuroprotective agent in addition to its anti-inflammatory and antioxidant characteristics. The poor bioavailability and ...
The heart of the matter: Cardiac stem cells
(Tubitak Scientific, 2016)
Cardiovascular diseases are the primary cause of death in the world. Pharmacological and surgical approaches are the main treatment options for heart disease; however, heart transplantation may be the only option for ...
Quercetin enhances human sperm motility in a dose and time dependent manner
(Istanbul Medipol University, 2020)
The aim of this study was to investigate the effect of quercetin on the motility of ejaculated human spermatozoa in asthenozoospermic cases by using different doses and exposure times. Semen samples of 94 men were incubated ...