Ara
Toplam kayıt 263, listelenen: 21-30
Investigation of the effect of adalimumab on experimental brain injury in mice
(2019)
Aim: We aimed to investigate the neuroprotective role of adalimumab based on
the hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect".
Methods: ...
Protein kinaz C aktivatörü PMA’nın TRPV1 kanalları üzerindeki etkileri
(Hacettepe Üniversitesi, 2015)
TRP alt ailesinin bir üyesi olarak bilinen TRPV1 kanalları non-selektif katyon kanallarıdır. Bu kanalların en fazla bulunduğu dokular; arka kök gangliyon nöronları, vagal nöronlar ve trigeminal gangliyon nöronlarıdır. TRPV1 ...
Predicting the effects of repetitive transcranial magnetic stimulation on cognitive functions in patients with alzheimer's disease by automated EEG analysis
(Frontiers Media SA, 2022)
Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder that generally affects the elderly. Today, after the limited benefit of the pharmacological treatment strategies, numerous noninvasive brain ...
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish
(Taylor & Francis Ltd, 2022)
Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and ...
Identification of PDE10A related proteins via proteomic analysis
(İnönü University Faculty of Medicine, 2022)
Aim: Phosphodiesterase 10A (PDE10A) regulates the expression of secondary messengers of cyclic adenosine monophosphate and cyclic guanosine monophosphate, which control several intracellular signaling pathways. Recently, ...
Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
(Nature Publishing Group, 2019)
Although clinically apparent metastasis is associated with late stages of cancer development, micro-metastatic dissemination may be an early event. However, the fate of these early disseminated tumor cells (DTC) remains ...
Experimentally induced metamorphosis in highly regenerative axolotl (ambystoma mexicanum) under constant diet restructures microbiota
(Nature Publishing Group, 2018)
Axolotl (Ambystoma mexicanum) is a critically endangered salamander species and a model organism for regenerative and developmental biology. Despite life-long neoteny in nature and in captive-bred colonies, metamorphosis ...
In silico analysis of a highly mutated gene in cancer provides insight into abnormal mRNA splicing: Splicing factor 3B subunit 1k700e mutant
(MDPI AG, 2020)
Cancer is the second leading cause of death worldwide. The etiology of the disease has remained elusive, but mutations causing aberrant RNA splicing have been considered one of the significant factors in various cancer ...
Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits
(Wiley, 2018)
ObjectivesThe objective of this study was to investigate the wound healing activity of Capparis ovata var. palaestina fruit extract in mice. For this aim, wound healing, invitro antimicrobial and antioxidant activities, ...
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
(Elsevier Sciences Bv, 2017)
Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ...