ORCID "0000-0002-3325-8820" Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) için listeleme
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Agouti-related protein neuron circuits that regulate appetite
Sternson, Scott M.; Atasoy, Deniz (Karger, 2014)New tools for mapping and manipulating molecularly defined neural circuits have improved the understanding of how the central nervous system regulates appetite. Studies that focused on Agouti-related protein neurons, a ... -
Chemogenetic tools for causal cellular and neuronal biology
Atasoy, Deniz; Sternson, Scott M. (American Physiological Society, 2018)Chemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological ... -
A genetically specified connectomics approach applied to long-range feeding regulatory circuits
Atasoy, Deniz; Betley, Jan Nicholas; Li, Wei-Ping; Hong Su, Helen; Sertel, Sinem M.; Scheffer, Louis K.; Simpson, Julie H.; Fetter, Richard D.; Sternson, Scott M. (Nature Publishing Group, 2014)Synaptic connectivity and molecular composition provide a blueprint for information processing in neural circuits. Detailed structural analysis of neural circuits requires nanometer resolution, which can be obtained with ... -
Impaired melanocortin pathway function in prader-willi syndrome gene-magel2 deficient mice
Öncül, Merve; Dilsiz, Pelin; Ateş Öz, Edanur; Ateş, Tayfun; Aklan, İltan; Çelik, Eşref; Sayar Atasoy, Nilüfer; Atasoy, Deniz (Oxford University Press, 2018)Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder causing social and learning deficits, impaired satiety and severe childhood obesity. Genetic underpinning of PWS involves deletion of a chromosomal region with ... -
Inactivation of Magel2 suppresses oxytocin neurons through synaptic excitation-inhibition imbalance
Ateş, Tayfun; Öncül, Merve; Dilsiz, Pelin; Topçu, İskalen Cansu; Cıvaş, Cihan Civan; Alp, Muhammed İkbal; Aklan, İltan; Öz, Edanur Ateş; Yavuz, Yavuz; Yılmaz, Bayram; Atasoy, Nilüfer Sayar; Atasoy, Deniz (Academic Press Inc Elsevier Science, 2019)Prader-Willi and the related Schaaf-Yang Syndromes (PWS/SYS) are rare neurodevelopmental disorders characterized by overlapping phenotypes of high incidence of autism spectrum disorders (ASD) and neonatal feeding difficulties. ... -
MCH neuron activity ıs sufficient for reward and reinforces feeding
Dilsiz, Pelin; Aklan, İltan; Sayar Atasoy, Nilufer; Yavuz, Yavuz; Filiz, Gizem; Köksalar, Fulya; Ateş, Tayfun; Öncül, Merve; Çoban, İlknur; Ateş Öz, Edanur; Cebecioğlu, Utku; Alp, Muhammed İkbal; Yılmaz, Bayram; Atasoy, Deniz (Karger, 2020)Background: Melanin-concentrating hormone (MCH)-expressing neurons have been implicated in regulation of energy homeostasis and reward, yet the role of their electrical activity in short-term appetite and reward modulation ...