ORCID "0000-0002-0323-6153" Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) için listeleme
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Dual action of exosomes derived from in vitro A beta toxicity model: The role of age for pathological response
Beker, Merve; Günay, Necmeddin; Sarıkamış, Bahar; Kalkan Çakmak, Rabia; Erçin, Nilüfer; Altıntaş, Mehmet Özgen; Altunay, Serdar; Beker, Mustafa Çağlar; Sarı Ak, Duygu; Kılıç, Ülkan (Elsevier Ireland Ltd, 2023)Exosomes released from different cell types of the central nervous system play an essential role in the patho-genesis of Alzheimer's disease (AD). In this study, we aimed to create an animal model by injecting exosomes ... -
Phosphodiesterase 10A deactivation induces long-term neurological recovery, peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice
Beker, Mustafa Çağlar; Pençe, Mahmud Esad; Yağmur, Sümeyya; Çağlayan, Berrak; Çağlayan, Aysun; Kılıç, Ülkan; Yelkenci, Hayriye Ecem; Altıntaş, Mehmet Özgen; Çağlayan, Ahmet Burak; Doeppner, Thorsten Roland; Hermann, Dirk M.; Kılıç, Ertuğrul (Academic Press Inc., 2022)The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are involved in several neuronal functions. High PDE10A ... -
Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model
Ozansoy, Mehmet; Altıntaş, Mehmet Özgen; Ozansoy, Muzaffer Beyza; Günay, Necmeddin; Kılıç, Ertuğrul; Kılıç, Ülkan (Scientific and Technological Research Council of Turkey (TÜBİTAK), 2020)Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, ...