Yazar "Velioğlu, Halil Aziz" için Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) listeleme
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Chemogenetic inhibition of MCH neurons does not alter memory performance in mice
Mutlu Burnaz, Özlem; Yuluğ, Burak; Öncül, Merve; Çelik, Eşref; Sayar Atasoy, Nilüfer; Çankaya, Şeyda; Hanoğlu, Lütfü; Velioğlu, Halil Aziz (Elsevier Masson s.r.l., 2022)Memory storage in the brain is one of the most extensively studied subjects in neuroscience. However, due to the highly complex structure of the memory-related systems in the brain, the mystery remains unsolved. Consolidation ... -
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: A randomised, double-blinded, placebo-controlled phase-II trial
Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Hacimuftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Türkez, Hasan; Borén, Jan; Uhlén, Mathias; Mardinoglu, Adil (BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed ... -
Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
Ayyıldız, Sevilay; Velioğlu, Halil Aziz; Ayyıldız, Behçet; Sütçübaşı, Bernis; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Yıldırım, Süleyman; Atasever, Alper; Yuluğ, Burak (Wiley, 2023)The claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical ... -
DLPF targeted repetitive transcranial magnetic stimulation improves brain glucose metabolism along with the clinical and electrophysiological parameters in CBD patients
Toprak, Güven; Hanoğlu, Lütfü; Çakır, Tansel; Güntekin, Bahar; Velioğlu, Halil Aziz; Yuluğ, Burak (Bentham Science Publishers, 2022)Background: Corticobasal Degeneration (CBD) is a rare neurological disease caused by the pathological accumulation of tau protein. The primary pathological features of CBD include progressive neurodegenerative processes ... -
The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model
Avnioğlu, Seda; Güngör, Meltem; Kurutaş, Ergül; Öztürk, Ünal; Demirhan, İlter; Bakariş, Sevgi; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak (University Press, 2022)Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative ... -
Evaluating the clinical significance of diazepam binding inhibitor in alzheimer's disease: A comparison with inflammatory, oxidative, and neurodegenerative biomarkers
Gökçe, Mustafa; Velioğlu, Halil Aziz; Bektay, Muhammed Yunus; Güler, Eray Metin (Karger, 2023)Introduction: Alzheimer's disease (AD) is one of the pathologies that the scientific world is still desperate for. The aim of this study was the investigation of diazepam binding inhibitor (DBI) as a prognostic factor for ... -
Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress
Velioğlu, Halil Aziz; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Toprak, Güven; Güler, Eray Metin; Bektay, Muhammed Yunus; Mutlu Burnaz, Özlem; Yuluğ, Burak (Academic Press Inc., 2021)Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify ... -
Neuroimaging-guided transcranial magnetic and direct current stimulation in MCI: Toward an individual, effective and disease-modifying treatment
Hanoğlu, Lütfü; Velioğlu, Halil Aziz; Hanoğlu, Taha; Yuluğ, Burak (SAGE Publications Inc, 2023)The therapeutic approaches currently applied in Alzheimer's disease (AD) and similar neurodegenerative diseases are essentially based on pharmacological strategies. However, despite intensive research, the effectiveness ... -
Neuropsychiatric outcomes and caregiver distress in primary progressive aphasia
Seçkin, Mustafa; Yıldırım, Elif; Demir, İlayda; Orhun, Ömer; Bülbül, Ezgi; Velioğlu, Halil Aziz; Öktem, Öget; Yeşilot, Nilüfer; Çoban, Oğuzhan; Gürvit, Hakan (Wiley, 2023)Background: In this study, we aimed to outline the neuropsychiatric consequences of primary progressive aphasia (PPA) and to understand how neuropsychiatric symptomatology affects distress in caregivers. Methods: The ... -
Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates
Çankaya, Şeyda; Özdemir Öktem, Ece; Saatçi, Özlem; Velioğlu, Halil Aziz; Uygur, Abdullah Burak; Özşimşek, Ahmet; Hanoğlu, Lütfü; Yuluğ, Burak (Elsevier Science Ltd., 2020)Introduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and ... -
Predicting the effects of repetitive transcranial magnetic stimulation on cognitive functions in patients with alzheimer's disease by automated EEG analysis
Kayasandık, Cihan Bilge; Velioğlu, Halil Aziz; Hanoğlu, Lütfü (Frontiers Media SA, 2022)Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder that generally affects the elderly. Today, after the limited benefit of the pharmacological treatment strategies, numerous noninvasive brain ... -
Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method
Avnioğlu, Seda; Velioğlu, Halil Aziz; Çankaya, Şeyda; Yuluğ, Burak (Lippincott Williams & Wilkins, 2021)Background Quantitative analysis of the high-resolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are ... -
Stratification of the gut microbiota composition landscape across the alzheimer's disease continuum in a Turkish cohort
Yıldırım, Süleyman; Nalbantoğlu, Özkan Ufuk; Bayraktar, Abdulahad; Ercan, Fatma Betül; Gündoğdu, Aycan; Velioğlu, Halil Aziz; Göl, Mehmet Fatih; Ekinci Soylu, Ayten; Koç, Fatma; Aslan Gülpınar, Ezgi; Soğukkanlı Kadak, Kübra; Arıkan, Muzaffer; Mardinoğlu, Adil; Koçak, Mehmet; Köseoğlu, Emel; Hanoğlu, Lütfü (American Society for Microbiology, 2022)Alzheimer's disease (AD) is a heterogeneous disorder that spans a continuum with multiple phases, including preclinical, mild cognitive impairment, and dementia. Unlike for most other chronic diseases, human studies reporting ... -
A structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients
Velioğlu, Halil Aziz; Ayyıldız, Behçet; Ayyıldız, Sevilay; Sütçübaşı, Bernis; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Yuluğ, Burak (John Wiley and Sons Inc, 2023)In Alzheimer's disease (AD), structural and functional changes in the brain may give rise to disruption of specific cognitive functions. The aim of this study is to investigate the functional connectivity alterations in ... -
Therapeutic role of repetitive transcranial magnetic stimulation in Alzheimer's and Parkinson's disease: Electroencephalography microstate correlates
Hanoğlu, Lütfü; Toplutaş, Eren; Sarıçaoğlu, Mevhibe; Velioğlu, Halil Aziz; Yıldız, Sultan; Yuluğ, Burak (Frontiers Media SA, 2022)Introduction: The microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation ... -
Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Özdemir Öktem, Ece; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfü; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, Burak (Elsevier Ltd, 2021)Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ...