Yazar "Gage, Fred H." için Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) listeleme
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Differentiation of inflammation-responsive astrocytes from glial progenitors generated from human induced pluripotent stem cells
Santos, Renata; Vadodaria, Krishna C.; Jaeger, Baptiste N.; Mei, Arianna; Lefcochilos-Fogelquist, Sabrina; Mendes, Ana P. D.; Erikson, Galina; Shokhirev, Maxim; Randolph-Moore, Lynne; Fredlender, Callie; Dave, Sonia; Oefner, Ruth; Fitzpatrick, Conor; Pena, Monique; Barron, Jerika J.; Ku, Manching; Denli, Ahmet M.; Kerman, Bilal Ersen; Charnay, Patrick; Kelsoe, John R.; Marchetto, Maria C.; Gage, Fred H. (Cell Press, 2017)Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce functional human astrocytes represents an advance in the study of ... -
Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination
Kerman, Bilal Ersen; Genoud, Stephane; Kurt Vatandaşlar, Burcu; Denli, Ahmet Murat; Ghosh, Shereen Georges; Xu, Xiangdong; Yeo, Gene W.; Aimone, James Bradley; Gage, Fred H. (American Society for Biochemistry and Molecular Biology Inc, 2020)Disorders that disrupt myelin formation during development or in adulthood, such as multiple sclerosis and peripheral neuropathies, lead to severe pathologies, illustrating myelin's crucial role in normal neural functioning. ... -
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
Marchetto, Maria Carolina; Hrvoj-Mihic, Branka; Kerman, Bilal Ersen; Yu, Diana X.; Vadodaria, Krishna C.; Linker, Sara B.; Narvaiza, Inigo; Santos, Renata; Denli, Ahmet M.; Mendes, Ana P. D.; Oefner, Ruth; Cook, Jonathan; McHenry, Lauren; Grasmick, Jaeson M.; Heard, Kelly; Fredlender, Callie; Randolph-Moore, Lynne; Kshirsagar, Rijul; Xenitopoulos, Rea; Chou, Grace; Hah, Nasun; Muotri, Alysson R.; Padmanabhan, Krishnan; Semendeferi, Katerina; Gage, Fred H. (Elife Sciences Publications Ltd, 2019)Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often ... -
α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy
Ettle, Benjamin; Kerman, Bilal Ersen; Valera-Martin, Elvira; Gillmann, Clarissa; Schlachetzki, Johannes Carolus Magnus; Reiprich, Simone; Büttner, Christian; Ekici, Arif Bülent; Reis, André; Wegner, Michael M.; Baüerle, Tobias J.; Riemenschneider, Markus Johannes; Masliah, Eliezer; Gage, Fred H.; Winkler, Jürgen (Springer, 2016)Multiple system atrophy (MSA) is a rare atypical parkinsonian disorder characterized by a rapidly progressing clinical course and at present without any efficient therapy. Neuropathologically, myelin loss and neurodegeneration ...