Yazar "Aklan, İltan" için Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) listeleme
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Impaired melanocortin pathway function in prader-willi syndrome gene-magel2 deficient mice
Öncül, Merve; Dilsiz, Pelin; Ateş Öz, Edanur; Ateş, Tayfun; Aklan, İltan; Çelik, Eşref; Sayar Atasoy, Nilüfer; Atasoy, Deniz (Oxford University Press, 2018)Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder causing social and learning deficits, impaired satiety and severe childhood obesity. Genetic underpinning of PWS involves deletion of a chromosomal region with ... -
Inactivation of Magel2 suppresses oxytocin neurons through synaptic excitation-inhibition imbalance
Ateş, Tayfun; Öncül, Merve; Dilsiz, Pelin; Topçu, İskalen Cansu; Cıvaş, Cihan Civan; Alp, Muhammed İkbal; Aklan, İltan; Öz, Edanur Ateş; Yavuz, Yavuz; Yılmaz, Bayram; Atasoy, Nilüfer Sayar; Atasoy, Deniz (Academic Press Inc Elsevier Science, 2019)Prader-Willi and the related Schaaf-Yang Syndromes (PWS/SYS) are rare neurodevelopmental disorders characterized by overlapping phenotypes of high incidence of autism spectrum disorders (ASD) and neonatal feeding difficulties. ... -
MCH neuron activity ıs sufficient for reward and reinforces feeding
Dilsiz, Pelin; Aklan, İltan; Sayar Atasoy, Nilufer; Yavuz, Yavuz; Filiz, Gizem; Köksalar, Fulya; Ateş, Tayfun; Öncül, Merve; Çoban, İlknur; Ateş Öz, Edanur; Cebecioğlu, Utku; Alp, Muhammed İkbal; Yılmaz, Bayram; Atasoy, Deniz (Karger, 2020)Background: Melanin-concentrating hormone (MCH)-expressing neurons have been implicated in regulation of energy homeostasis and reward, yet the role of their electrical activity in short-term appetite and reward modulation ... -
NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways
Aklan, İltan; Sayar Atasoy, Nilufer; Yavuz, Yavuz; Ateş, Tayfun; Çoban, İlknur; Köksalar, Fulya; Filiz, Gizem; Topçu, İskalen Cansu; Öncül, Merve; Dilsiz, Pelin; Cebecioğlu, Utku; Alp, Muhammed İkbal; Yılmaz, Bayram; Davis, Deborah R.; Hajdukiewicz, Karolina; Saito, Kenji; Konopka, Witold; Cui, Huxing; Atasoy, Deniz (Cell Press, 2020)Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the ...