ORCID "0000-0003-4292-5717" Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) için listeleme
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FDG-PET scanning shows distributed changes in cortical activity associated with visual hallucinations in eye disease
Hanoğlu, Lütfü; Yıldız, Sultan; Çakır, Tansel; Hanoğlu, Taha; Yuluğ, Burak (Bentham Science Publ Ltd, 2019)Background and Objective: Charles Bonnet Syndrome (CBS) has been defined as complex visual hallucinations (CVH) due to visual loss. The underlying mechanism of CBS is not clear and the underlying pathophysiology of the ... -
Functional neural networks stratify Parkinson's disease patients across the spectrum of cognitive impairment
Hajebrahimi, Farzin; Budak, Miray; Sarıcaoğlu, Mevhibe; Temel, Zeynep; Kahraman Demir, Tuğçe; Hanoğlu, Lütfü; Yıldırım, Süleyman; Bayraktaroğlu, Zübeyir (Wiley, 2024)Introduction Cognitive impairment (CI) is a significant non-motor symptoms in Parkinson's disease (PD) that often precedes the emergence of motor symptoms by several years. Patients with PD hypothetically progress from ... -
Impairment in recognition of emotional facial expressions in Alzheimer's disease is represented by EEG theta and alpha responses
Güntekin, Bahar; Hanoǧlu, Lütfü; Aktürk, Tuba; Ruşen, Ece; Yıldırım, Ebru; Yener, Görsev (Blackwell Publishing Inc., 2019)Behavioral studies have shown that the recognition of facial expressions may be impaired in patients with Alzheimer's disease (AD). The identification and recognition of a facial expression might be represented by event-related ... -
Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress
Velioğlu, Halil Aziz; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Toprak, Güven; Güler, Eray Metin; Bektay, Muhammed Yunus; Mutlu Burnaz, Özlem; Yuluğ, Burak (Academic Press Inc., 2021)Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify ... -
Metaproteogenomic analysis of saliva samples from Parkinson's disease patients with cognitive impairment
Arıkan, Muzaffer; Kahraman Demir, Tuğçe; Yıldız, Zeynep; Nalbantoğlu, Özkan Ufuk; Korkmaz, Nur Damla; Helvacı Yılmaz, Nesrin; Şen, Aysu; Özcan, Mutlu; Muth, Thilo; Hanoğlu, Lütfü; Yıldırım, Süleyman (Nature Portfolio, 2023)Cognitive impairment (CI) is very common in patients with Parkinson's Disease (PD) and progressively develops on a spectrum from mild cognitive impairment (PD-MCI) to full dementia (PDD). Identification of PD patients at ... -
Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy
Yuluğ, Burak; Ozansoy, Mehmet; Alökten, Merve; Çetin Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Hanoğlu, Lütfü; Kılıç, Ülkan; Kılıç, Ertuğrul (2020)Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. ... -
The multifactorial role of pre-supplementary motor area stimulation in the freezing of gait: An alternative strategy to the classical drug-Target approach
Sarıcaoğlu, Mevhibe; Hanoğlu, Lütfü; Toprak, Güven; Helvacı Yılmaz, Nesrin; Yuluğ, Burak (Bentham Science Publishers, 2022)Introduction: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA ... -
Neuroimaging-guided transcranial magnetic and direct current stimulation in MCI: Toward an individual, effective and disease-modifying treatment
Hanoğlu, Lütfü; Velioğlu, Halil Aziz; Hanoğlu, Taha; Yuluğ, Burak (SAGE Publications Inc, 2023)The therapeutic approaches currently applied in Alzheimer's disease (AD) and similar neurodegenerative diseases are essentially based on pharmacological strategies. However, despite intensive research, the effectiveness ... -
The neuroprotective effect of focused ultrasound: New perspectives on an old tool
Yuluğ, Burak; Hanoğlu, Lütfü; Kılıç, Ertuğrul (Pergamon-Elsevier Science Ltd., 2017)Introduction Transcranial focused ultrasound (tFUS) is a novel technique that can noninvasively modulate the cortical function. Moreover, there are rapidly replicating evidence suggesting the role of tFUS for targeted ... -
Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates
Çankaya, Şeyda; Özdemir Öktem, Ece; Saatçi, Özlem; Velioğlu, Halil Aziz; Uygur, Abdullah Burak; Özşimşek, Ahmet; Hanoğlu, Lütfü; Yuluğ, Burak (Elsevier Science Ltd., 2020)Introduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and ... -
Power spectral density and coherence analysis of eye disease with and without visual hallucination
Yıldız, Sultan; Yuluğ, Burak; Kocabora, Mehmet Selim; Hanoğlu, Lütfü (Elsevier Ireland Ltd, 2021)Objectives: Charles Bonnet Syndrome (CBS) is a rare clinical condition which has been defined as complex visual hallucinations (CVH) due to visual loss. This study investigated differences in the EEG power spectral density ... -
Predicting the effects of repetitive transcranial magnetic stimulation on cognitive functions in patients with alzheimer's disease by automated EEG analysis
Kayasandık, Cihan Bilge; Velioğlu, Halil Aziz; Hanoğlu, Lütfü (Frontiers Media SA, 2022)Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder that generally affects the elderly. Today, after the limited benefit of the pharmacological treatment strategies, numerous noninvasive brain ... -
Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study
Babiloni, Claudio; Noce, Giuseppe; Ferri, Raffaele; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Zurrón, Montserrat; Díaz, Fernando; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Hünerli Gündüz, Duygu; Onorati, Paolo; Stocchi, Fabrizio; Vacca, Laura; Maestú, Fernando; Frisoni, Giovanni B.; del Percio, Claudio (Oxford University Press Inc, 2022)In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors ... -
Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment
Babiloni, Claudio; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hanoğlu, Lütfü; Yener, Görsev; Özbek, Yağmur; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; del Percio, Claudio (IOS Press, 2021)Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha ... -
Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia
Babiloni, Claudio; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Fama, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hanoğlu, Lütfü; Yener, Görsev; Emek Savaş, Derya Durusu; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; Del Percio, Claudio (Elsevier, 2020)Extending Basar's theory of event-related EEG oscillations, here we hypothesize that even in quiet wakefulness, transient increases in delta rhythms may enhance global cortical arousal as revealed by the desynchronization ... -
The savant syndrome: a gift or a disability? A deeper look into metabolic correlates of hidden cognitive capacity
Onin, İrem; Hanoğlu, Lütfü; Yuluğ, Burak (Bentham Science Publishers, 2023)Savant syndrome is a rare and unusual condition that occurs in the presence of severe developmental disabilities, disorders, and injuries. The syndrome can be congenital from birth to childhood or acquired as a result of ... -
Stratification of the gut microbiota composition landscape across the alzheimer's disease continuum in a Turkish cohort
Yıldırım, Süleyman; Nalbantoğlu, Özkan Ufuk; Bayraktar, Abdulahad; Ercan, Fatma Betül; Gündoğdu, Aycan; Velioğlu, Halil Aziz; Göl, Mehmet Fatih; Ekinci Soylu, Ayten; Koç, Fatma; Aslan Gülpınar, Ezgi; Soğukkanlı Kadak, Kübra; Arıkan, Muzaffer; Mardinoğlu, Adil; Koçak, Mehmet; Köseoğlu, Emel; Hanoğlu, Lütfü (American Society for Microbiology, 2022)Alzheimer's disease (AD) is a heterogeneous disorder that spans a continuum with multiple phases, including preclinical, mild cognitive impairment, and dementia. Unlike for most other chronic diseases, human studies reporting ... -
A structural and resting-state functional connectivity investigation of the pulvinar in elderly individuals and Alzheimer's disease patients
Velioğlu, Halil Aziz; Ayyıldız, Behçet; Ayyıldız, Sevilay; Sütçübaşı, Bernis; Hanoğlu, Lütfü; Bayraktaroğlu, Zübeyir; Yuluğ, Burak (John Wiley and Sons Inc, 2023)In Alzheimer's disease (AD), structural and functional changes in the brain may give rise to disruption of specific cognitive functions. The aim of this study is to investigate the functional connectivity alterations in ... -
Therapeutic role of repetitive transcranial magnetic stimulation in Alzheimer's and Parkinson's disease: Electroencephalography microstate correlates
Hanoğlu, Lütfü; Toplutaş, Eren; Sarıçaoğlu, Mevhibe; Velioğlu, Halil Aziz; Yıldız, Sultan; Yuluğ, Burak (Frontiers Media SA, 2022)Introduction: The microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation ... -
Therapeutic role of rifampicin in Alzheimer's disease
Yuluğ, Burak; Hanoǧlu, Lütfü; Ozansoy, Mehmet; Işık, Doğan; Kılıç, Ülkan; Kılıç, Ertuğrul; Schabitz, Wolf Rüdiger (Wiley, 2018)Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its ...