WoS Q Kategorisi "Q1" Rektörlüğe Bağlı Birimler İçin Listeleme
Toplam kayıt 160, listelenen: 21-40
-
Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice
(Elsevier Ltd, 2021)Research question: Does chronic stress affect the key proteins and sperm parameters of the blood & ndash;testis barrier (BTB)? Design: C57Bl/6 mice were divided into two groups: a non-treated control group and a chronic ... -
Clinical evaluation and resting state fMRI analysis of virtual reality based training in Parkinson's disease through a randomized controlled trial
(Nature Research, 2022)There are few studies investigating the short-term effects of Virtual Reality based Exergaming (EG) on motor and cognition simultaneously and pursue the brain functional activity changes after these interventions in patients ... -
Clopidogrel exerts neuroprotective effect in experimental traumatic brain injury
(Wiley-Blackwell, 2016)... -
A co-culture-based multiparametric imaging technique to dissect local H2O2 signals with targeted HyPer7
(MDPI, 2021)Multispectral live-cell imaging is an informative approach that permits detecting biological processes simultaneously in the spatial and temporal domain by exploiting spectrally distinct biosensors. However, the combination ... -
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: A randomised, double-blinded, placebo-controlled phase-II trial
(BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed ... -
Comparison of 3 cell-free matrix scaffolds used to treat osteochondral lesions in a rabbit model
(SAGE Publications Inc., 2022)Background: Various cell-free scaffolds are already in use for the treatment of osteochondral defects (OCDs); however, a gold standard material has not yet been defined. Purpose: This study compared the macroscopic, ... -
Complexities of the chemogenetic toolkit: Differential mDAAO activation by D-amino substrates and subcellular targeting
(Elsevier Inc., 2021)A common approach to investigate oxidant-regulated intracellular pathways is to add exogenous H2O2 to living cells or tissues. However, the addition of H2O2 to the culture medium of cells or tissues approach does not ... -
Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ
(Endocrine Society, 2016)Context: Lower TSH screening cutoffs have doubled the ascertainment of congenital hypothyroidism (CH), particularly cases with a eutopically located gland-in-situ (GIS). Although mutations in known dyshormonogenesis genes ... -
Conditioned medium derived from neural progenitor cells induces long-term post-ischemic neuroprotection, sustained neurological recovery, neurogenesis, and angiogenesis
(Springer, 2017)Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic ... -
Curcumin- and Piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of Curcumin on HCT116 colorectal cancer model
(Frontiers in Bioengineering and Biotechnology, 2020)Combination chemotherapy, administrating two chemotherapeutic agents concurrently, comes into prominence, as the heterogeneity or the level of the disease necessitates a collaborative action. Curcumin, isolated from turmeric, ... -
Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents
(Elsevier, 2020)In drug-resistant phytopathogenic fungi, there has been extensive research on microbiological and antifungal drug development. In this study, a novel series of cylopentapyrazole bearing a 1,2,3-thiadiazole ring 2a-e were ... -
Detecting and targeting neurodegenerative disorders using electrospun nanofibrous matrices: Current status and applications
(Taylor & Francis Ltd, 2021)Neurodegeneration is defined as the progressive atrophy and loss of function of neurons; it is present in neurodegenerative disorders such as Multiple Sclerosis, Alzheimer's, Huntington's, and Parkinson's diseases. The ... -
Development of a chemogenetic approach to manipulate intracellular pH
(American Chemical Society, 2023)Chemogenetic Operation of iNTRacellular prOton Levels(pH-Control)is a novel substrate-based enzymatic method that enables precise spatiotemporalcontrol of ultralocal acidification in cultured cell lines and primaryneurons. ... -
Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy
(Elsevier B.V., 2023)Drug resistant and undetectable tumors easily escape treatment leading metastases and/or recurrence of the lethal disease. Therefore, it is vital to diagnose and destroy micro tumors using simple yet novel approaches. Here, ... -
Differentiation of claustrum resting-state functional connectivity in healthy aging, Alzheimer's disease, and Parkinson's disease
(Wiley, 2023)The claustrum is a sheet-like of telencephalic gray matter structure whose function is poorly understood. The claustrum is considered a multimodal computing network due to its reciprocal connections with almost all cortical ... -
Differentiation of inflammation-responsive astrocytes from glial progenitors generated from human induced pluripotent stem cells
(Cell Press, 2017)Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce functional human astrocytes represents an advance in the study of ... -
Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro
(John Wiley and Sons Inc, 2021)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ... -
Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor
(National Academy of Sciences, 2017)Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the receptor tyrosine kinase KIT. To genetically dissect in vivo the requirement of different signal transduction pathways emanating from ...