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Residues in the fructose-binding pocket are required for ketohexokinase-A activity
Ferreira, Juliana C.; Villanueva, Adrian J.; Fadl, Samar; Al Adem, Kenana; Cinviz, Zeynep Nur; Nedyalkova, Lyudmila; Cardoso, Thyago H.S.; Andrade, Mario Edson; Saksena, Nitin K.; Şensoy, Özge; Rabeh, Wael M. (2024)Excessive fructose consumption is a primary contributor to the global surges in obesity, cancer, and metabolic syndrome. Fructolysis is not robustly regulated and is initiated by ketohexokinase (KHK). In this study, we ...