Erişim şekli için "info:eu-repo/semantics/openAccess" Makale Koleksiyonu listeleme
Toplam kayıt 42, listelenen: 21-40
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Formulation of acid-sensitive micelles for delivery of cabazitaxel into prostate cancer cells
(Amer Chemical Soc, 2016)We report the synthesis of an amphiphilic triblock copolymer composed of a hydrophilic polyethylene glycol) (PEG) block, a central poly(acrylic acid) (PAA) block, and a hydrophobic poly(methyl methacrylate) (PMMA) block ... -
How to reduce stress on the pedicle screws in thoracic spine? Importance of screw trajectory: A finite element analysis
(Turkish Neurosurgical Society, 2019)AIM: To investigate the biomechanical comparison of thoracic transpedicular screw trajectories on the sagittal plane. MATERIAL and METHODS: A three-dimensional, non-linear finite element analysis (FEA) model of T8 through ... -
Influence of three-dimensional reconstruction method for building a model of the cervical spine on its biomechanical responses: A finite element analysis study
(Hindawi Publishing Corporation, 2016)In some finite element analysis studies of models of sections of the spine, the three-dimensional solid model is built by assuming symmetry about the mid-sagittal plane of the section, whereas in other studies, the model ... -
Investigation into cervical spine biomechanics following single, multilevel and hybrid disc replacement surgery with dynamic cervical implant and fusion: A finite element study
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Cervical fusion has been a standard procedure for treating abnormalities associated with the cervical spine. However, the reliability of anterior cervical discectomy and fusion (ACDF) has become arguable due to its adverse ... -
Lumbar single-level dynamic stabilization with semi-rigid and full dynamic systems: A retrospective clinical and radiological analysis of 71 patients
(Korean Orthopaedic Association, 2017)Background: This study compares the clinical and radiological results of three most commonly used dynamic stabilization systems in the field of orthopedic surgery. Methods: A total of 71 patients underwent single-level ... -
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
(Elsevier B.V., 2022)Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ... -
Neuroprotective effects of curcumin-loaded emulsomes in a laser axotomy-induced CNS injury model
(Dove Medical Press Ltd, 2020)Purpose: Curcumin, a polyphenol isolated from the rhizomes of turmeric, holds great potential as a neuroprotective agent in addition to its anti-inflammatory and antioxidant characteristics. The poor bioavailability and ... -
A novel fontan Y-graft for interrupted inferior vena cava and azygos continuation
(Elsevier Science, 2022)Objectives: To evaluate the hemodynamicdynamic advantage of a new Fontan surgical template that is intended for complex single-ventricle patients with interrupted inferior vena cava-azygos and hemi-azygos continuation. The ... -
Novel synthetic approaches for bisnaphthalimidopropyl (BNIP) derivatives as potential anti-parasitic agents for the treatment of leishmaniasis
(MDPI, 2019)Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, ... -
Optimizing percutaneous pulmonary valve implantation with patient-specific 3D-printed pulmonary artery models and hemodynamic assessment
(Frontiers Media SA, 2024)Background: Percutaneous pulmonary valve implantation (PPVI) has emerged as a less invasive alternative for treating severe pulmonary regurgitation after tetralogy of Fallot (TOF) repair in patients with a native right ... -
Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan (TM)) platform
(Elsevier Science, 2017)Vascular invasion is a pathological hallmark of hepatocellular carcinoma (HCC), associated With poor prognosis; it is strongly related to the early recurrence and poor survival after curative resection. In order to determine ... -
Quantitative phase macroscopic system for label-free imaging of tissue sections
(İstanbul University, 2021)Optical microscopes are typically designed as versatile tools that are capable of imaging at various modalities with different resolutions in respective visual fields. A large extend of versatility causes increased complexity, ... -
Radiation type- and dose-specific transcriptional responses across healthy and diseased mammalian tissues
(MDPI, 2022)Ionizing radiation (IR) is a genuine genotoxic agent and a major modality in cancer treatment. IR disrupts DNA sequences and exerts mutagenic and/or cytotoxic properties that not only alter critical cellular functions but ... -
Real-time holographic tracking and control of microrobots
(IEEE-Inst Electrical Electronics Engineers Inc, 2017)Digital holography is used to track the three-dimensional position of a magnetic microrobot maneuvered in real time by means of an electromagnetic manipulation system. The method presented is able to process holograms at ... -
The role of positive and negative pressure on cavitation nucleation in nanodroplet-mediated histotripsy
(Iop Publishing Ltd, 2016)Nanodroplet-mediated histotripsy (NMH) is an ultrasound ablation technique combining histotripsy with acoustically sensitive perfluorocarbon (PFC) nanodroplets that can be selectively delivered to tumor cells for targeted ... -
S-layer fusion protein as a tool functionalizing emulsomes and CurcuEmulsomes for antibody binding and targeting
(Elsevier, 2015)Selective targeting of tumor cells by nanoparticle-based drug delivery systems is highly desirable because it maximizes the drug concentration at the desired target while simultaneously protecting the surrounding healthy ... -
Selective binding of pVTK peptide-and bisphosphonate-functionalized micelles to prostate cancer cells, osteoblasts, and osteoclasts
(Andover House, Inc., 2022)This report describes the development of functionalized polymeric micelles encapsulating a chemotherapeutic agent. The results indicate the ability to achieve selective uptake into different cell populations in metastatic ... -
A simple yet time-optimal and linear-space algorithm for shortest unique substring queries
(Elsevier, 2015)We revisit the problem of finding shortest unique substring (SUS) proposed recently by Pei et al. (2013) [12]. We propose an optimal O(n) time and space algorithm that can find an SUS for every location of a string of size ... -
Temperature and pH-dependent behaviors of mAb drugs: A case study for trastuzumab
(MDPI, 2022)The distortions in the high-order structure of therapeutic monoclonal antibodies (mAbs) under different environmental conditions acutely affect mAb stability, resulting in altered safety, efficacy, and shelf-life profiles. ... -
Toward building hybrid biological/in silico neural networks for motor neuroprosthetic control
(Frontiers Research Foundation, 2015)In this article, we introduce the Bioinspired Neuroprosthetic Design Environment (BNDE) as a practical platform for the development of novel brain-machine interface (BMI) controllers, which are based on spiking model ...