Güncel Gönderiler: Makale Koleksiyonu
Toplam kayıt 284, listelenen: 1-20
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Synthesis and anticancer activity of novel indole derivatives as dual EGFR/SRC kinase inhibitors
(2024)Background: Recent studies showed that the cooperation between c-SRC and EGFR is responsible for more aggressive phenotype in diverse tumors, including glioblastomas and carcinomas of the colon, breast, and lung. Studies ... -
Chemical characterization and biological properties of oyster and shiitake mushrooms extracts and their liposomal formulations
(2024)In recent years, the production of liposomal formulations using mushroom extracts has gained increasing interest to increase the bioavailability of bioactive compounds in the nutraceutical field. Based on this information, ... -
Aflatoxins, fumonisins, citrinin, and zearalenone contents and health risk estimates in bee products in Turkey
(2024)Food contamination is an important global food safety issue. This study aimed to detect aflatoxins (AFB1, AFB2, AFG1, AFG2), fumonisins (FB1, FB2), citrinin (CIT), and zearalenone (ZEA) in four bee product groups (honey, ... -
Autism spectrum disorder: evaluation of community-based screening program
(2024)Background/aim: This study was conducted to evaluate the results of autism spectrum disorder (ASD) screenings conducted in a region of İstanbul between 2018 and 2023. Materials and methods: This descriptive study was ... -
Effect of trastuzumab and lonidamine-loaded lipid nanoparticles (lnp) on her2+ breast cancer
(2024)Our study involves inhibition of glycolysis and inhibition of the HER2 pathway, which is highly expressed in many types of cancer. Decreased survival, negative metastasis, and induced apoptosis are expected due to the ... -
New 8-heterocyclic xanthine derivatives as antiproliferative agents: Synthesis and biological evaluation
(2024)This research focuses on the synthesis, characterization, and evaluation of the anti-cancer activity of novel 8-aryl substituted 1,3-diethylxanthine derivatives. The anti-proliferative activities of all the compounds were ... -
Chitosan-based buccal mucoadhesive bilayer tablets enhance the bioavailability of tizanidine hydrochloride by bypassing the first-pass metabolism
(2024)Tizanidine hydrochloride (TZN) is an antimuscarinic agent used in the treatment of pain-related spasms, multiple sclerosis, and stroke-related spasticity. It has low oral bioavailability (40 %) due to excessive first-pass ... -
Is ChatGPT reliable and accurate in answering pharmacotherapy-related inquiries in both Turkish and English?
(2024)Introduction: Artificial intelligence (AI), particularly ChatGPT, is becoming more and more prevalent in the healthcare field for tasks such as disease diagnosis and medical record analysis. The objective of this study is ... -
Sprayable microemulsion of diphenhydramine hydrochloride for dermal delivery
(2024)In this work, a sprayable microemulsion of diphenhydramine hydrochloride (DPH HCl) was developed for use in conditions that cause itching, such as insect bites, mild sunburns, and skin irritations. Microemulsions were ... -
HPLC investigation of hidden danger deoxynivalenol (vomitoxin) in baby foods from grain sources in Türkiye
(2024)The Food and Agricultural Organization (FAO) declared that at minimum, one quarter of the earth’s food supply is infected with mycotoxins. Deoxynivalenol (DON) is the most common Fusarium mycotoxin in maize, wheat, rice ... -
Enzyme-based antiviral potential of cinnamomum verum j. presl. essential oil and ıts major component (e)-cinnamaldehyde
(2024)In the present study, Cinnamomum verum J. Presl. bark essential oil and its main component cinnamaldehyde was evaluated in vitro for neuraminidase (NA), transmembrane serine protease (TMPRSS2), and angiotensin converting ... -
Novel microemulsion containing benzocaine and fusidic acid simultaneously: Formulation, characterization, and in vitro evaluation for wound healing
(Springer Science and Business Media Deutschland GmbH, 2024)Modern drug carrier technologies, such as microemulsions with small droplet sizes and high surface areas, improve the ability of low water solubility active ingredients to permeate and localize. The goal of this study was ... -
Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne
(Marmara University, 2024)Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different ... -
Synthesis of new imidazo[1,2-a]pyridine triazole hybrid molecules as potential apoptotic antitumor agents
(John Wiley and Sons Inc, 2024)Novel imidazo[1,2-a]pyridines bearing 1,2,3-triazole moieties at the C3 position were synthesized. After the characterization of the synthesized compounds, their in vitro therapeutic activities were evaluated in various ... -
Determination of aflatoxins and ochratoxin a levels in nuts and dried fruits in Turkey with evaluation of the estimated daily intake
(VUP Food Research Institute, 2023)A total of 140 samples, including nuts and dried fruits sold in the province of Istanbul, Turkey, were examined for the presence of aflatoxins and ochratoxin A (OTA) by high-performance liquid chromatography (HPLC), which ... -
Separate and mutual effects of BIRB796 and bortezomib on pHsp27 and viability of U87MG glioma cells
(Pleiades Publishing, 2023)Hsp27 phosphorylation is associated with many pathways in glioma, such as tumor cell proliferation and apoptosis inhibition. The aim of this study is to examine the separate and mutual effects of BIRB796 and bortezomib on ... -
Phytochemical screening, biological evaluation, anatomical, and morphological investigation of Ferula tingitana L. (Apiaceae)
(Springer Wien, 2023)Ferula tingitana L. is a high perennial plant and its leaf is an alternate arrangement and yellow, and its flowers are unisexual like other Apiaceae. It has been used as a spice and for various medicinal purposes in the ... -
In vitro anti-inflammatory activities of Tanacetum parthenium L. extract and its major metabolite parthenolide
(Istanbul Medipol University, 2024)Tanacetum parthenium L. (Feverfew) is daisy-like Asteraceae plant carrying sesquiterpene lactones; used for the treatment of migraine and anti-inflamma-tory effect. This study aims to evaluate T. parthenium extract and ... -
Phytochemical profile and antioxidant activity potential of Lotus sanguineus (Vural) D.D.Sokoloff
(Istanbul Medipol University, 2024)The in vitro antioxidant activity and phenol, phenolic acid, flavonoid, and proanthocyanidin content of Lotus sanguineus (Vural) D.D.Sokolof extracts were investigated. The aerial parts of Lotus sanguineus have high ... -
The effect of decolonization-decontamination prophylaxis versus traditional prophylaxis in orthopedic surgery in Kosovo
(Istanbul Medipol University, 2024)This study aimed to compare empirical prophylactic treatment with decoloni-zation-decontamination prophylaxis protocol in order to reduce surgical site infections. The study was conducted in Kosovo Ortomedica Orthopedic ...