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Toplam kayıt 265, listelenen: 31-40
3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: A family of antiproliferative thiazolidines
(Royal Society of Chemistry, 2015)
Cancer results from unregulated cell growth. Reactivating the process of the programmed cell death, i.e. apoptosis, is a classical anticancer therapeutic strategy. The apoptosis-inducing property of the (2RS,4R)-2-phenyl ...
Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors
(Elsevier B.V., 2022)
Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ...
Chemical compositon, antibacterial and antioxidant activities of Cnidium silaifolium ssp. orientale (Boiss.) Tutin essential oils
(Consejo Superior de Investigaciones Científicas (CSIC), 2021)
The chemical compositions of the essential oils (EOs) obtained by hydrodistillation from different parts of Cnidium silaifolium ssp. orientale (Boiss.) Tutin were analyzed both by GC-FID and GC/MS, simultaneously. One ...
Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; Physicochemical properties, in vitro release and oral acute toxicity
(Faculdade de Ciencias Farmaceuticas (Biblioteca), 2019)
Inorganic and carbon based nanomaterials are widely used against several diseases, such as cancer, autoimmune diseases as well as fungi and bacteria colonization. In this work, Santa Barbara Amorphous mesoporous silica ...
Butyrylcholinesterase-inhibiting natural coumarin molecules as potential leads
(Elsevier Ltd, 2021)
Seventeen natural coumarin derivatives; badrakemin (1), 14′-acetoxybadrakemin (2), badrakemone (3), 14′-acetoxybadrakemone (4), colladonin (5), colladonin acetate (6), 14′-acetoxycolladonin (7), karatavicinol (8), deltoin ...
In vitro ACE2 and 5-LOX enzyme inhibition by menthol and three different mint essential oils
(SAGE Publications Inc., 2021)
Mentha arvensis L., M. citrata L., and M. spicata L. (family Lamiaceae) essential oils, and their characteristic constituent, menthol, were evaluated in vitro for angiotensin converting enzyme 2 (ACE2) and 5-lipoxygenase ...
In vitro bioavailability studies on phytochemical profile and antioxidant activity potential of clematis viticella L.
(Marmara University, 2019)
Since biotransformation processes generally affect the biological activities of phytochemical compounds, bioavailability is one of the primary steps in determining the potency of the activity. Previous studies have shown ...
Development and in vitro evaluation of theophylline loaded matrix tablets prepared with direct compression
(Association of Pharmaceutical Teachers of India, 2016)
The objectives of the present study are to develop novel sustained release matrix tablets of theophylline and to evaluate release properties and kinetic behaviour of these tablets. The formulations have been prepared in ...
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2021)
Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated with thiouracil and thiocytosine derivatives, which are well ...
Platinum(II)-thiosemicarbazone drugs override the cell resistance due to glutathione; assessment of their activity against human adenocarcinoma cells
(Taylor & Francis Ltd, 2016)
New platinum(II) compounds of the thiosemicarbazone 1-(1H-Benzimidazol-2-yl)ethan-1-one thiosemicarbazone (BzimetTSCH), [Pt(BzimetTSCH)Cl]center dot 2H(2)O (1) and [Pt(BzimetTSCH)(tpp)]Cl center dot H2O center dot MeCN (2) ...