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Toplam kayıt 19, listelenen: 11-19
Pyridine-substituted thiazolylphenol derivatives: Synthesis, modeling studies, aromatase inhibition, and antiproliferative activity evaluation
(Wiley-VCH Verlag, 2018)
Drugs used in breast cancer treatments target the suppression of estrogen biosynthesis. During this suppression, the main goal is to inhibit the aromatase enzyme that is responsible for the cyclization and structuring of ...
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives
(Pergamon-Elsevier Science Ltd, 2018)
Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their ...
Molecular modelling and activity analysis of mycobacterium tuberculosis DNA gyrase B ATPase active site
(University of Istanbul, 2017)
Computer-based algorithms and statistical techniques such as receiver operating characteristic (ROC) curves are increasingly used for the design of new ligands. X-ray crystallographic data and homology models allow examining ...
Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles
(İstanbul Medipol University, 2019)
Thiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. In recent, third generation cephalosporins include thiazole ring system. In this study, we synthesized 33 piperazine ...
Design and synthesis of new donepezil analogs derived from arylpiperazine scaffold as acetylcholinesterase inhibitors
(Taylor & Francis Ltd, 2020)
Newly synthesized 4-substituted phenyl-2-(4-substituted phenylpiperazine-1-yl)thiazole derivatives (4a-v) were evaluated in terms of their acetylcholinesterase (AChE) inhibition activities. Twenty-two compounds were tested ...
Synthesis and in vitro antitumor activities of novel thioamide substituted piperazinyl-1,2,4-triazines
(Wiley, 2022)
Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3-triazine, 1,3,5-triazine (s-triazine) and 1,2,4-triazine. All of these skeletons were ...
Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs
(Scientific and Technical Research Council of Turkey, 2020)
Marine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its ...
Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles
(Scientific Technical Research Council Turkey-Tubitak, 2021)
Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives ...
Synthesis and antibacterial evaluation of novel benzimidazole, benzothiazole, benzofurane, and naphtofurane derivatives of aminothiazoles
(Ankara Association of Pharmaceutical Sciences, 2022)
The thiazole ring is the core of bioactive molecules that generate broad activity. These activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In this work, starting from seconder/cyclic amines, ...