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Benzotriazole-oxadiazole hybrid compounds: Synthesis, anticancer activity, molecular docking and ADME profiling studies
(Elsevier B.V., 2022)
Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized using both conventional method and ultrasound sonication (US) as an environmentally friendly method. It was observed that the US method ...
Novel benzimidazole derivatives: Cytotoxic and apoptotic properties on lung cancer cell line
(Bentham Science Publishers, 2020)
Background: Benzimidazole derivatives are privileged molecules known to have a wide variety of biological activities. In medicinal chemistry, due to the ring's structural similarity to nucleotides, its derivatives were ...
Design, synthesis and biological evaluation of novel tetralone/indanone containing thiosemicarbazone derivatives with selective COX-2 inhibition as anticancer agents
(Elsevier B.V., 2023)
A series of novel tetralone/indanone moiety-bearing thiosemicarbazone derivatives were synthesized and evaluated for their biological activities. The structural elucidations of the compounds were performed by IR spectroscopy, ...
Cytotoxic activity and docking studies of 2-arenoxybenzaldehyde N-acyl hydrazone and 1,3,4-oxadiazole derivatives against various cancer cell lines
(MDPI, 2022)
To understand whether previously synthesized novel hydrazone and oxadiazole derivatives have promising anticancer effects, docking studies and in vitro toxicity assays were performed on A-549, MDA-MB-231, and PC-3 cell ...