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Toplam kayıt 67, listelenen: 1-10
An optimization study on solid lipid nanoparticles using artificial neural network
(Colegio Farmaceuticos Provincia De Buenos Aires, 2017)
Common use of supportive programs in finding the best in R&D studies provides positive results and thus ensures benefits to companies in terms of cost and time. The aim of this work was to develop, evaluate and optimize ...
Investigation of antioxidant and cytotoxic activities of Opuntia ficus-indica (L.) Mill. fruit extract
(Istanbul University, 2019)
Opuntia ficus-indica fruits are claimed to possess several health-beneficial properties. This study was carried out to determine the phytochemicals as well as to compare antioxidant activity and cell viability of the ...
Discovery of novel potent human chondrosarcoma (SW1353) inhibitors: 4-(2/3/4-pyridyl)thiazole 2-acetamide derivatives
(Elsevier B.V., 2023)
Chondrosarcoma is the most common cartilage sarcoma among adult patients. It is mainly observed after the degradation of chondrocytes in the case of cell stress. Unfortunately, the mortality among patients is high as a ...
Rosmarinus officinalis L. essential oil encapsulated in new microemulsion formulations for enhanced antimicrobial activity
(Wiley, 2022)
In this present study, Rosmarinus officinalis essential oil and its new microemulsions (MEs) were evaluated both for the in vitro antibacterial and antifungal activity. The essential oil composition was verified initially ...
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish
(Taylor & Francis Ltd, 2022)
Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and ...
Seminal trace elements and their relationship with sperm parameters
(Wiley, 2022)
Male reproductive problems may derive from many reasons including the environmental toxicants which may either intaken by occupational exposure, nutrition or bad air quality. The increased exposure to these substances due ...
Phytochemical analysis, antioxidant, and enzyme inhibition activity of five Salvia taxa from Turkey
(Elsevier B.V., 2023)
Salvia L. species are widely used for treatment of different disorders in traditional Turkish medicine. In this study, the methanol extracts of five Salvia taxa, including S. aucheri subsp. canescens, S. aytachii, S. ...
Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors
(Elsevier B.V., 2022)
Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ...
Butyrylcholinesterase-inhibiting natural coumarin molecules as potential leads
(Elsevier Ltd, 2021)
Seventeen natural coumarin derivatives; badrakemin (1), 14′-acetoxybadrakemin (2), badrakemone (3), 14′-acetoxybadrakemone (4), colladonin (5), colladonin acetate (6), 14′-acetoxycolladonin (7), karatavicinol (8), deltoin ...
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2021)
Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated with thiouracil and thiocytosine derivatives, which are well ...