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Toplam kayıt 4, listelenen: 1-4
Thiazole-substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors
(Wiley, 2018)
Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE). Studies on Alzheimer's disease (AD) in the mid-20th century proved ...
Novel thiazole-piperazine derivatives as potential cholinesterase inhibitors
(Wiley, 2019)
Dementia is a cognitive disorder mostly associated with Alzheimer's disease (AD) in addition to being seen in many other diseases of the central nervous system (CNS). The limited number of drugs is not sufficient to provide ...
Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives
(Wiley, 2019)
The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal chemists. In addition, thiosemicarbazones are among the most potent and ...
Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles
(Scientific Technical Research Council Turkey-Tubitak, 2021)
Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives ...