ORCID "0000-0003-2533-5141" Makale Koleksiyonu için listeleme
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Anatolicin, a highly potent and selective cytotoxic sesquiterpene coumarin from the root extract of heptaptera anatolica
Tosun, Fatma; Beutler, John A.; Ransom, Tanya; Miski, Mahmut (MDPI, 2019)Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based ... -
Biological activities of the fruit essential oil, fruit, and root extracts of ferula drudeana korovin, the putative anatolian ecotype of the silphion plant
Tosun, Fatma; Göger, Fatih; İşcan, Gökalp; Kürkçüoğlu, Mine; Kuran, Fadil Kaan; Miski, Mahmut (MDPI, 2023)In the present study, preliminary phytochemical investigations were performed on the fruit essential oil and antioxidant-rich methanolic extracts of the fruits and roots of Ferula drudeana, the putative Anatolian ecotype ... -
Biological activities of the natural coumarins from apiaceae plants
Tosun, Fatma; Biltekin, Sevde Nur; Karadağ, Ayşe Esra; Mıhoğlugil, Feyyaz; Akalgan, Demet; Miski, Mahmut (ACG Publications, 2023)Nineteen natural coumarins; badrakemin (1), colladonin (2), 14'-acetoxybadrakemin (3), anatolicin (4), 14'-hydroxycolladonin (5), badrakemone (6), karatavicinol (7), 14'-acetoxybadrakemone (8), 14'-acetoxycolladonin (9), ... -
Biological activity and chemical composition of the essential oil from the fruits of Ferula halophila Peşmen
Kürkçüoğlu, Mine; İşcan, Gökalp; Tosun, Fatma; Miski, Mahmut (Istanbul Medipol University, 2023)The hydrodistilled essential oils of the dried fruits of F. halophila Peşmen, an endemic species growing near Salt Lake in Central Anatolia, were analyzed by GC and GC-MS systems; 27 and 24 compounds representing 92.1% and ... -
Biological activity and chemical composition of the essential oil from the fruits of Ferula rigidula Fisch. ex DC.
İşcan, Gökalp; Kürkçüoğlu, Mine; Tosun, Fatma; Miski, Mahmut (Istanbul Medipol University, 2023)The hydro-distilled essential oils of the fruits of F. rigidula Fisch. ex DC. was analyzed by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC/MS) systems at the same time. Thirty-one compounds were ... -
Butyrylcholinesterase-inhibiting natural coumarin molecules as potential leads
Erdoğan Orhan, İlkay; Tosun, Fatma; Şenol Deniz, Fatma Sezer; Eren, Gökçen; Mıhoğlugil, Feyyaz; Akalgan, Demet; Miski, Mahmut (Elsevier Ltd, 2021)Seventeen natural coumarin derivatives; badrakemin (1), 14′-acetoxybadrakemin (2), badrakemone (3), 14′-acetoxybadrakemone (4), colladonin (5), colladonin acetate (6), 14′-acetoxycolladonin (7), karatavicinol (8), deltoin ... -
Chemical characterization of Glaucosciadium cordifolium (Boiss.) B. L. Burtt & P. H. Davis essential oils and their antimicrobial, and antioxidant activities
Karadağ, Ayşe Esra; Demirci, Betül; Çeçen, Ömer; Tosun, Fatma (Istanbul University, 2019)Chemical composition of volatile oils obtained from the roots, fruits and aerial parts of Glaucosciadium cordifolium (Boiss.) B. L. Burtt& P. H. Davis (Apiaceae) were analyzed using gas chromatography-flame ionization ... -
Chemical compositon, antibacterial and antioxidant activities of Cnidium silaifolium ssp. orientale (Boiss.) Tutin essential oils
Karadağ, Ayşe Esra; Demirci, Betül; Çeçen, Ömer; Tosun, Fatma; Demirci, Fatih (Consejo Superior de Investigaciones Científicas (CSIC), 2021)The chemical compositions of the essential oils (EOs) obtained by hydrodistillation from different parts of Cnidium silaifolium ssp. orientale (Boiss.) Tutin were analyzed both by GC-FID and GC/MS, simultaneously. One ... -
Coumarins from the Dichloromethane Root Extract of Heptaptera triquetra and Their Cytotoxic Activities
Tosun, Fatma; Beutler, John A.; Miski, Mahmut (ACG Publications, 2023)A known dihydrofuranocoumarin ester; deltoin (1), together with five known sesquiterpene coumarin ethers; umbelliprenin (2), farnesyl scopoletin (3), karatavicinol (4), colladonin (5), colladin (6), and a novel sesquiterpene ... -
Cytotoxic activity of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin
Tosun, Fatma; Miski, Mahmut (Istanbul Medipol University, 2022)Cytotoxic activities of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichlorometh-ane extract of the fruits of H. anatolica showed the ... -
Cytotoxic activity of the fruit extracts of heptaptera cilicica (boiss. & balansa) tutin
Mihoğlugil, Feyyaz; Tosun, Fatma; Miski, Mahmut (2024)The fruit extracts of Heptaptera cilicica (Boiss. & Balansa) Tutin were screened for cytotoxic activities on the colon (COLO205 and KM12) and kidney (UO31 and A498) cancer cell lines. The highest cytotoxic activities were ... -
Cytotoxic activity of the root and fruit extracts of Heptaptera anisoptera (DC.) Tutin
Tosun, Fatma; Miski, Mahmut (İstanbul Medipol University, 2020)Cytotoxic activities of the root and fruit extracts of Heptaptera anisoptera (DC.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichloromethane extract of the roots of H. anisoptera showed ... -
Cytotoxic sesquiterpene coumarins from the roots of heptaptera cilicica
Tosun, Fatma; Aytar, Erdi Can; Beutler, John A.; Wilson, Jennifer A.; Miski, Mahmut (ACG Publications, 2021)Preliminary 2-day cancer cell screening assays indicated that the dichloromethane extract of the roots of Heptaptera cilicica showed relatively strong cytotoxic activity. Eleven sesquiterpene coumarin ethers with potent ... -
Cytotoxicity screening of some Turkish plants against renal cancer cells
Mihoğlugil, Feyyaz; Akalgan, Demet; Tosun, Fatma (Marmara University, 2023)In this contribution, we performed cytotoxicity screening of 51 extracts from 17 plant species, representing 14 families growing in Turkey. Cytotoxic activities of the dichloromethane, ethyl acetate, and methanol extracts ... -
Determination of the volatile compounds of anthemis cretica subsp. Anatolica (boiss.) grierson
Kürkçüoǧlu, Mine K.; Tosun, Fatma (Badebio Biotechnololgy Ltd, 2020)Chemical composition of the essential oils obtained by hydrodistillation from the aerial parts of Anthemis cretica subsp. anatolica was analyzed by gas chromatography (GC) and gas chromatography-mass spectroscopy (GC-MS) ... -
The essential oils of two Achillea L. Species from Turkey
Tosun, Fatma; Kürkçüoǧlu, Mine (İstanbul Medipol University, 2018)Chemical composition of the essential oils obtained by hydrodistillation from the aerial parts of Achillea biebersteinii Afan. and A. wilhelmsii C. Koch were analyzed by GC-FID and GC-MS. The essential oils of A. biebersteinii ... -
Hemostatic activity of cistus creticus extract in wistar albino rats
Karadağ, Ayşe Esra; Çaşkurlu, Ayşegül; Okur, Mehmet Evren; Güzelmeriç, Etil; Üstündağ Okur, Neslihan; Tosun, Fatma; Yeşilada, Erdem; Demirci, Fatih (Springer Nature, 2020)Aerial part preparations of Cistus creticus L., Cistaceae, are traditionally used in Anatolia as a hemostatic agent. The air-dried aerial parts were extracted with methanol. Gels were prepared, followed by the hemostatic ... -
In vitro anti-helicobacter pylori and antimycobacterial activity evaluation of selected plants from Turkey
In this study, the extracts of Ulmus minor Mill. subsp. minor (Ulmaceae), Lathyrus pratensis L. (Leguminosae), Glaucium leiocarpum Bois. (Papaveraceae), and Echium vulgare L. (Boraginacea) were investigated for their in ... -
In vitro antifungal activity of cistus creticus l. Against plant pathogenic fungi
Çaşkurlu, Ayşegül; Karadağ, Ayşe Esra; Köse, Yavuz Bülent; Tosun, Fatma (Istanbul Medipol University, 2020)Cistus creticus L. is a well-known member of the Cistaceae family. In this present study, methanol extract of aerial parts of C. creticus was evaluated for its antifungal activity against plant pathogenic fungi such as ... -
In vitro antimicrobial and antioxidant activity evaluation of melampyrum arvense L. Var. elatius boiss. and sedum spurium m. bieb. extracts
Karadağ, Ayşe Esra; Tosun, Fatma (İstanbul Medipol University, 2019)Sedum spurium M. Bieb. (Crassulaceae) is a common ornamental plant, whereas, Melampyrum arvense L. var. elatius Boiss. (Orobanchaceae) is a semi-parasitic plant and grows naturally in the fields. In this study, the ...