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Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles
Şahin, Zafer; Koçoğlu Kalkan, Melike; Berk, Barkın; Yurttaş, Leyla; Bender, Ceysu; Biltekin Kaleli, Sevde Nur; Demirayak, Şeref (Scientific Technical Research Council Turkey-Tubitak, 2021)Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives ...