Erişim şekli için "info:eu-repo/semantics/embargoedAccess" Makale Koleksiyonu listeleme
Toplam kayıt 67, listelenen: 1-20
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Anti-inflammatory, analgesic and in vivo-in vitro wound healing potential of the Phlomis rigida Labill. extract
(Elsevier Ireland Ltd, 2021)Ethnopharmacological relevance: The preparations of Phlomis aerial parts are used traditionally in Anatolia for wound healing and in inflammatory disorders. Methods: For the identification of the active fraction, the air ... -
Antimicrobial, anticholinesterase evaluation and chemical characterization of essential oil Phlomis kurdica Rech. fil. Growing in Turkey
(Taylor and Francis Inc., 2020)The Phlomis kurdica Rech.fil. (Lamiaceae) essential oil was investigated for its chemical constituents and in vitro biological activities. Volatile components were characterized, antimicrobial and anticholinesterase ... -
Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: Formulation, characterization, in vitro-ex vivo evaluation
(Taylor & Francis Ltd, 2022)In this study, hydrogels containing azelaic acid were developed using chitosan or HPMC (1-7%) for local treatment of acne vulgaris. Physicochemical properties such as viscosity, pH and mechanical properties were evaluated. ... -
Benzotriazole-oxadiazole hybrid compounds: Synthesis, anticancer activity, molecular docking and ADME profiling studies
(Elsevier B.V., 2022)Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized using both conventional method and ultrasound sonication (US) as an environmentally friendly method. It was observed that the US method ... -
Biocompatibility of biomimetic multilayered alginate-chitosan/beta-TCP scaffold for osteochondral tissue
(Elsevier Science, 2015)Biomimetic three-layered monolithic scaffold (TLS) intended for treatment of osteochondral defects was fabricated by using freeze drying method. The multilayered material was prepared with chitosan (C) and alginate (A) ... -
Biological activities of the natural coumarins from apiaceae plants
(ACG Publications, 2023)Nineteen natural coumarins; badrakemin (1), colladonin (2), 14'-acetoxybadrakemin (3), anatolicin (4), 14'-hydroxycolladonin (5), badrakemone (6), karatavicinol (7), 14'-acetoxybadrakemone (8), 14'-acetoxycolladonin (9), ... -
Biological properties and HPLC analyses of four medicinal plants extracts obtained at different extraction temperatures
(Wiley, 2022)In the present study, extracts of four medicinal plants (Cajanus cajan, Carica papaya, Morinda morindoides, and Senna alexandrina) obtained at two different extraction temperatures (24 and 45 degrees C) were investigated ... -
Butyrylcholinesterase-inhibiting natural coumarin molecules as potential leads
(Elsevier Ltd, 2021)Seventeen natural coumarin derivatives; badrakemin (1), 14′-acetoxybadrakemin (2), badrakemone (3), 14′-acetoxybadrakemone (4), colladonin (5), colladonin acetate (6), 14′-acetoxycolladonin (7), karatavicinol (8), deltoin ... -
Chemical characterization and multidirectional biological effects of different solvent extracts of arum elongatum: in vitro and in silico approaches
(Wiley-VCH Verlag, 2023)Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual ... -
Chitosan-based buccal mucoadhesive patches to enhance the systemic bioavailability of tizanidine
(Elsevier B.V., 2023)Tizanidine hydrochloride (TZN) is a muscle relaxant used to treat a variety of disorders such as painful muscle spasms and chronic spasticity. TZN has low oral bioavailability due to extensive first-pass metabolism and is ... -
Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-beta reveals anticancer effect in breast cancer
(Wiley, 2023)Background: Platelet derived growth factors (PDGF)-D and the expression of its receptor increase in neoplastic progression of cancer. Co-silencing of growth factor and receptor can be suggested as an important strategy for ... -
A comparative investigation on the in vitro anti-inflammatory, antioxidant and antimicrobial potentials of subextracts from the aerial parts of Daphne oleoides Schreb. subsp oleoides
(Elsevier, 2017)Daphne oleoides Schreb. subsp. oleoides is an evergreen shrub which is known for its folkloric usage against various ailments such as arthritic and infectious diseases. The aim of the present study was to comparatively ... -
Coumarins from the Dichloromethane Root Extract of Heptaptera triquetra and Their Cytotoxic Activities
(ACG Publications, 2023)A known dihydrofuranocoumarin ester; deltoin (1), together with five known sesquiterpene coumarin ethers; umbelliprenin (2), farnesyl scopoletin (3), karatavicinol (4), colladonin (5), colladin (6), and a novel sesquiterpene ... -
Cytotoxic activity of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin
(Istanbul Medipol University, 2022)Cytotoxic activities of the fruit extracts of Heptaptera anatolica (Boiss.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichlorometh-ane extract of the fruits of H. anatolica showed the ... -
Design and synthesis of new donepezil analogs derived from arylpiperazine scaffold as acetylcholinesterase inhibitors
(Taylor & Francis Ltd, 2020)Newly synthesized 4-substituted phenyl-2-(4-substituted phenylpiperazine-1-yl)thiazole derivatives (4a-v) were evaluated in terms of their acetylcholinesterase (AChE) inhibition activities. Twenty-two compounds were tested ... -
Design, synthesis and biological evaluation of novel tetralone/indanone containing thiosemicarbazone derivatives with selective COX-2 inhibition as anticancer agents
(Elsevier B.V., 2023)A series of novel tetralone/indanone moiety-bearing thiosemicarbazone derivatives were synthesized and evaluated for their biological activities. The structural elucidations of the compounds were performed by IR spectroscopy, ... -
Determination of aflatoxins and ochratoxin a levels in nuts and dried fruits in Turkey with evaluation of the estimated daily intake
(VUP Food Research Institute, 2023)A total of 140 samples, including nuts and dried fruits sold in the province of Istanbul, Turkey, were examined for the presence of aflatoxins and ochratoxin A (OTA) by high-performance liquid chromatography (HPLC), which ... -
Determination of mycotoxins by HPLC, LC-MS/MS and health risk assessment of the mycotoxins in bee products of Turkey
(NLM (Medline), 2023)The aim of this study is to determine the levels of deoxynivalenol (DON), HT-2 toxin (HT2), T-2 toxin (T2), and ochratoxin A (OTA) in bee products (bee pollen, propolis, honey and royal jelly) available in Turkey. In ... -
Development and evaluation of mesoporous montmorillonite/magnetite nanocomposites loaded with 5-Fluorouracil
(Elsevier, 2020)Porous magnetic nanomaterials have attracted great attention in a variety of applications, particularly in the magnetically targeted and/or controlled release of various species. In this study, a new route was determined ... -
Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy
(Elsevier B.V., 2023)Drug resistant and undetectable tumors easily escape treatment leading metastases and/or recurrence of the lethal disease. Therefore, it is vital to diagnose and destroy micro tumors using simple yet novel approaches. Here, ...