Yayıncı "Elsevier B.V." Makale Koleksiyonu için listeleme
Toplam kayıt 7, listelenen: 1-7
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Benzotriazole-oxadiazole hybrid compounds: Synthesis, anticancer activity, molecular docking and ADME profiling studies
(Elsevier B.V., 2022)Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized using both conventional method and ultrasound sonication (US) as an environmentally friendly method. It was observed that the US method ... -
Chitosan-based buccal mucoadhesive patches to enhance the systemic bioavailability of tizanidine
(Elsevier B.V., 2023)Tizanidine hydrochloride (TZN) is a muscle relaxant used to treat a variety of disorders such as painful muscle spasms and chronic spasticity. TZN has low oral bioavailability due to extensive first-pass metabolism and is ... -
Design, synthesis and biological evaluation of novel tetralone/indanone containing thiosemicarbazone derivatives with selective COX-2 inhibition as anticancer agents
(Elsevier B.V., 2023)A series of novel tetralone/indanone moiety-bearing thiosemicarbazone derivatives were synthesized and evaluated for their biological activities. The structural elucidations of the compounds were performed by IR spectroscopy, ... -
Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy
(Elsevier B.V., 2023)Drug resistant and undetectable tumors easily escape treatment leading metastases and/or recurrence of the lethal disease. Therefore, it is vital to diagnose and destroy micro tumors using simple yet novel approaches. Here, ... -
Discovery of novel potent human chondrosarcoma (SW1353) inhibitors: 4-(2/3/4-pyridyl)thiazole 2-acetamide derivatives
(Elsevier B.V., 2023)Chondrosarcoma is the most common cartilage sarcoma among adult patients. It is mainly observed after the degradation of chondrocytes in the case of cell stress. Unfortunately, the mortality among patients is high as a ... -
Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors
(Elsevier B.V., 2022)Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ... -
Phytochemical analysis, antioxidant, and enzyme inhibition activity of five Salvia taxa from Turkey
(Elsevier B.V., 2023)Salvia L. species are widely used for treatment of different disorders in traditional Turkish medicine. In this study, the methanol extracts of five Salvia taxa, including S. aucheri subsp. canescens, S. aytachii, S. ...