ORCID "0000-0002-1693-9579" Makale Koleksiyonu için listeleme
-
Chitosan modification-enhanced silencing effect of Ad5-shPDGF-D vector in breast cancer cell line MDA-MB-231
Ekentok Atıcı, Ceyda; Akbuğa, Jülide (Bentham Science Publishers, 2023)Background: Gene therapeutics are being developed to treat metastatic breast tumors, which are mostly resistant to conventional therapies. Targeting platelet-derived growth factor-D (PDGF-D) is a viable approach because ... -
Combination therapy with chitosan/siRNA nanoplexes targeting PDGF-D and PDGFR-beta reveals anticancer effect in breast cancer
Şalva, Emine; Özbaş, Suna; Alan, Saadet; Özkan, Naziye; Ekentok Atıcı, Ceyda; Kabasakal, Levent; Akbuğa, Jülide (Wiley, 2023)Background: Platelet derived growth factors (PDGF)-D and the expression of its receptor increase in neoplastic progression of cancer. Co-silencing of growth factor and receptor can be suggested as an important strategy for ... -
Effects of chitosan nanoparticles with long synthetic siRNAs targeting VEGF in triple-negative breast cancer cells
Cömez, Birnur; Akbuğa, Jülide (Faculdade de Ciencias Farmaceuticas (Biblioteca), 2023)Vascular endothelial growth factor (VEGF) is an essential angiogenic factor in breast cancer development and metastasis. Small interfering RNAs (siRNAs) can specifically silence genes via the RNA interference pathway, ... -
Evaluation of the effect of honey-containing chitosan/hyaluronic acid hydrogels on wound healing
Şalva, Emine; Akdağ, Ahmet Enes; Alan, Saadet; Arısoy, Sema; Akbuğa, Fatma Jülide (Multidisciplinary Digital Publishing Institute (MDPI), 2023)The 3D polymeric network structure of hydrogels imitates the extracellular matrix, thereby facilitating cell growth and differentiation. In the current study, chitosan/hyaluronic acid/honey coacervate hydrogels were produced ... -
Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes
Şalva, Emine; Alan, Saadet; Karakoyun, Berna; Çakalağaoğlu, Fulya; Özbaş, Suna; Akbuğa, Jülide (Universidade de São Paulo, 2022)Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing ... -
Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-thione derivatives
Kandemir, Levent; Karakuş, Sevgi; Özbaş, Suna; Rollas, Sevim; Akbuğa, Julide (Marmara University, 2022)In this study, a series of 1,3,4-thiadiazole (1b-9b) and l,2,4-triazole-3-thione (1c-9c) derivatives were synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted thiosemicarbazide ...