Yayın tarihi için Makale Koleksiyonu listeleme
Toplam kayıt 280, listelenen: 61-80
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New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents
(Elsevier Science Bv, 2017)The synthesis of 3-[3/4-(2-aryl-2-oxoethoxy) arylidene] chroman/thiochroman-4-one derivatives (1-34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis ... -
Characterization of Opuntia ficus-indica (L.) Mill. fruit volatiles and antibacterial evaluation
(Badebio Biotechnololgy Ltd, 2018)Opuntia ficus-indica (L.) Mill. fruits known as prickly pear cactus are used in folk medicine as well as food. In the present study it was aimed to extract the volatile constituents of O. ficus-indica fruits by n-hexane. ... -
Investigation of genotoxicity risk and DNA repair capacity in breast cancer patients using anastrozole
(Kare Publishing, 2018)OBJECTIVE: Breast cancer is the most common cancer in women worldwide and the incidence increases in postmenopausal women. Anastrozole is a non-steroidal (type II), third-generation aromatase inhibitor (AI) that is used ... -
Thiazole-substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors
(Wiley, 2018)Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE). Studies on Alzheimer's disease (AD) in the mid-20th century proved ... -
Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet
(Marmara University, 2018)The oral application of drugs is the most popular route for achieving systemic effects, nevertheless, it is limited by difficulties related to physicochemical properties of the drug. Solid lipid nanoparticles (SLNs) are ... -
Pyridine-substituted thiazolylphenol derivatives: Synthesis, modeling studies, aromatase inhibition, and antiproliferative activity evaluation
(Wiley-VCH Verlag, 2018)Drugs used in breast cancer treatments target the suppression of estrogen biosynthesis. During this suppression, the main goal is to inhibit the aromatase enzyme that is responsible for the cyclization and structuring of ... -
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
(Elsevier Science Bv, 2018)Oleander (Nerium oleander L., fain: Apocynaceae) is an evergreen shrub. Although it is known to be poisonous to humans, a large number of utilizations in folk medicine have been reported against diabetes, rheumatic pain ... -
Synthesis and characterizations of novel thiazolyl-thiadiazole derivatives as telomerase activators
(Scientific Technical Research Council Turkey-Tubitak, 2018)Pyridine-3/4-thiocarboxamide derivatives were used as starting materials for the synthesis of the target compounds. The pyridine-3/4-thiocarboxamide derivatives were reacted with ethyl 2-chloroacetoacetate in ethanol to ... -
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives
(Pergamon-Elsevier Science Ltd, 2018)Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their ... -
Miyokardiyal iskemi sonrası gelişen akut böbrek hasarı üzerine Nebivolol’ün etkisi: Preklinik bir çalışma
(Galenos Yayıncılık, 2018)Amaç: Akut miyokard iskemisinin reperfüzyonu (IR) sırasında miyokard dokusunun yanı sıra diğer dokularda da hasarın söz konusu olduğu gösterilmiştir. Böbrek hasarı bunlardan birisidir. Altta yatan mekanizmalara yönelik pek ... -
Evaluation of the in vitro anti-inflammatory activity of Nerium oleander L. flower extracts and activity-guided isolation of the active constituents
(ACG Publications, 2018)The in vitro anti-inflammatory activity profile of the Nerium oleander flower EtOH extract/its subextracts (n-hexane, CH2Cl2, EtOAc, remaining H2O) were evaluated on LPS induced Raw 264.7 macrophages. The effects of the ... -
In vitro antimicrobial and antioxidant activity of some berry species
(Istanbul Medipol University, 2018)The aim of this work was to determine antioxidant and antimicrobial activities of extracts obtained from fresh and dried fruits of Vaccinium macrocarpon, Morus nigra, Fragaria X ananassa. Antioxidant and antimicrobial ... -
Investigation of antimicrobial activities of some herbs containing essential oils and their mouthwash formulations
(Turkish Pharmacists Association, 2018)Objectives: The aim of this study was to prepare pharmaceutical formulations of mouthwashes and to examine the antimicrobial activities of essential oils obtained from plants used traditionally in Turkey for oral infections. ... -
The essential oils of two Achillea L. Species from Turkey
(İstanbul Medipol University, 2018)Chemical composition of the essential oils obtained by hydrodistillation from the aerial parts of Achillea biebersteinii Afan. and A. wilhelmsii C. Koch were analyzed by GC-FID and GC-MS. The essential oils of A. biebersteinii ... -
Comparison of 3 doses of aloe vera and burn drugs in market on burnt rat models
(İstanbul Medipol University, 2018)Burn injuries are an incident that can have serious traumatic consequences. Degree of tissue damage depends on height of heat and duration of contact. It can be classified as 4 different burn degrees. Herbal treatments can ... -
A contraindication to metfromin therapy: Renal impairment - Adherence to prescribing guidelines at a hospital in Turkey
(University of Istanbul, 2018)Objective: The aim of this study was to investigate whether renal functions of the patients were monitored and checked before and during metformin treatment as recommended in guidelines or whether they were disregarded and ... -
A survey on awareness, knowledge, and attitudes toward epilepsy in an urban community in turkey
(Wolters Kluwer Medknow Publications, 2018)Background and Aim: Epilepsy is one of the most common chronic neurological disorders with a high prevalence. Epileptic people and their family members suffer more from social stigma than the disorder itself. Among various ... -
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
(Elsevier Science Bv, 2018)The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ... -
Evaluation of the antidiabetic property of capparis ovata desf. Var. Palaestina zoh. Extracts using in vivo and in vitro approaches
(Bentham Science Publ Ltd, 2018)Background and Objective: This paper is focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. Methods: Alloxan-induced ... -
Chemical characterization of Glaucosciadium cordifolium (Boiss.) B. L. Burtt & P. H. Davis essential oils and their antimicrobial, and antioxidant activities
(Istanbul University, 2019)Chemical composition of volatile oils obtained from the roots, fruits and aerial parts of Glaucosciadium cordifolium (Boiss.) B. L. Burtt& P. H. Davis (Apiaceae) were analyzed using gas chromatography-flame ionization ...