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Novel benzydamine hydrochloride and chlorhexidine gluconate loaded bioadhesive films for local treatment of buccal infections
(Editions de Sante, 2023)Benzydamine hydrochloride (BZD), chlorhexidine gluconate (CHG) or their combination are frequently used as liquid dosage forms for the local treatment of buccal fungal and bacterial infections. However, the short residence ... -
Chemical characterization and multidirectional biological effects of different solvent extracts of arum elongatum: in vitro and in silico approaches
(Wiley-VCH Verlag, 2023)Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain, arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study investigated the antioxidant properties, individual ... -
In vivo wound-healing and in vitro antibacterial and antioxidant properties of Carduus adpressus extract
(Marmara University, 2023)Carduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Türkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the ... -
Cytotoxicity screening of some Turkish plants against renal cancer cells
(Marmara University, 2023)In this contribution, we performed cytotoxicity screening of 51 extracts from 17 plant species, representing 14 families growing in Turkey. Cytotoxic activities of the dichloromethane, ethyl acetate, and methanol extracts ... -
Design, synthesis and biological evaluation of novel tetralone/indanone containing thiosemicarbazone derivatives with selective COX-2 inhibition as anticancer agents
(Elsevier B.V., 2023)A series of novel tetralone/indanone moiety-bearing thiosemicarbazone derivatives were synthesized and evaluated for their biological activities. The structural elucidations of the compounds were performed by IR spectroscopy, ... -
Comparison of chemical profiles of aronia melanocarpa fruit extracts
(Turkish Science and Technology Publishing (TURSTEP), 2023)The chokeberry plant, which is native to North America and the south of Canada, is a deciduous, shrub-shaped, berry-like plant belonging to the Rosaceae family, which survives for many years. It is seen as a plant that ... -
Protective effects of momordica charantia (Bitter Melon) against metho-trexate-induced kidney damage
(Bentham Science Publishers, 2023)Background: Methotrexate is a cytotoxic chemotherapeutic agent that has severe side ef-fects, such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been shown to have antioxidant, ... -
Wound healing activity of arum maculatum
(Istanbul Medeniyet University, 2023)Objective: In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed ... -
The prevalence of drug-drug interactions and reported therapy related side-effects in oncology out-patients
(Marmara University, 2023)Objective: The use of multiple medications in cancer patients is unavoidable; thus, adverse drug-drug interactions are frequent. This study aims to assess the prevalence of potential drug interactions in oncology patients ... -
The effects of gold nanoparticles with different surface coatings and sizes on biochemical parameters in mice
(Prusa Medical Publishing, 2023)Objectives: Gold nanoparticles are very popular metallic nanomaterials and they have a wide spectrum of biomedical applications. This study was aimed to the production of stable and monodisperse polyethyleneimine (PEI) and ... -
In vivo wound-healing and in vitro antibacterial and antioxidant of Carduus extract
(Marmara University, 2023)Carduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Turkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the ... -
Chitosan modification-enhanced silencing effect of Ad5-shPDGF-D vector in breast cancer cell line MDA-MB-231
(Bentham Science Publishers, 2023)Background: Gene therapeutics are being developed to treat metastatic breast tumors, which are mostly resistant to conventional therapies. Targeting platelet-derived growth factor-D (PDGF-D) is a viable approach because ... -
Protective effects of momordica charantia (Bitter Melon) against methotrexate-induced kidney damage
(Bentham Science Publishers Ltd., 2023)Background Methotrexate is a cytotoxic chemotherapeutic agent that has severe side effects, such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been shown to have antioxidant, ... -
In vitro and in silico evaluation of ACE2 and LOX inhibitory activity of origanum essential oils and carvacrol
(Georg Thieme Verlag KG, 2023)Origanum spp. are used both for culinary purposes and for their biological activities. In this study, commercial Origanum majorana, Origanum minutiflorum, Origanum vulgare, and Origanum onites essential oils and their ... -
Chitosan-based buccal mucoadhesive patches to enhance the systemic bioavailability of tizanidine
(Elsevier B.V., 2023)Tizanidine hydrochloride (TZN) is a muscle relaxant used to treat a variety of disorders such as painful muscle spasms and chronic spasticity. TZN has low oral bioavailability due to extensive first-pass metabolism and is ... -
Effects of chitosan nanoparticles with long synthetic siRNAs targeting VEGF in triple-negative breast cancer cells
(Faculdade de Ciencias Farmaceuticas (Biblioteca), 2023)Vascular endothelial growth factor (VEGF) is an essential angiogenic factor in breast cancer development and metastasis. Small interfering RNAs (siRNAs) can specifically silence genes via the RNA interference pathway, ... -
Sesquiterpene coumarin ethers with selective cytotoxic activities from the roots of ferula huber-morathii Peşmen (Apiaceae) and unequivocal determination of the absolute stereochemistry of samarcandin
(MDPI, 2023)Ancient physicians frequently used the resin of Ferula species to treat cancer. Today, some folkloric recipes used for cancer treatment also contain the resin of Ferula species. The dichloromethane extract of the roots of ... -
Biological activity and chemical composition of the essential oil from the fruits of Ferula rigidula Fisch. ex DC.
(Istanbul Medipol University, 2023)The hydro-distilled essential oils of the fruits of F. rigidula Fisch. ex DC. was analyzed by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC/MS) systems at the same time. Thirty-one compounds were ... -
Morphological and biochemical investigation of the protective effects of panax ginseng on methotrexate-induced testicular damage
(Istanbul University Press, 2023)Objective: Methotrexate (MTX) is a chemotherapeutic agent that causes testicular toxicity used in the cure of various types of cancer. The anti-oxidant and anti-cancer effects of Panax ginseng (PxG) have been reported in ... -
Antibacterial properties of carvacrol against antibiotic-resistant bacteria, enteric bacteria, and oral pathogens
(Marmara University, 2023)The present study investigated the antibacterial activity of carvacrol against Vancomycin-Resistant Enterococci (VRE), Carbapenem-Resistant Enterobacteriaceae (CRE), Methicillin-Resistant Staphylococcus aureus (MRSA), ...