Başlık için Makale Koleksiyonu listeleme
Toplam kayıt 278, listelenen: 217-236
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Pyridine-substituted thiazolylphenol derivatives: Synthesis, modeling studies, aromatase inhibition, and antiproliferative activity evaluation
(Wiley-VCH Verlag, 2018)Drugs used in breast cancer treatments target the suppression of estrogen biosynthesis. During this suppression, the main goal is to inhibit the aromatase enzyme that is responsible for the cyclization and structuring of ... -
Quality by design approach for optimizing preparation and characterization of buccal film formulation with different polymers
(Advanced Scientific Research, 2019)Bilayered oromucosal film preparations (buccal films) offer a promising way to enable drug administration via the oral cavity. Polymeric film formulations containing chitosan, sodium alginate or carbopol were evaluated to ... -
A quantum chemical DFT/HF study on acidity constants of some benzothiazole and thiazole derivatives
(Council of Scientific and Industrial Research, 2014)The acid dissociation (K-a) constants of some 4-and/or 6-substituted-2-aminobenzothiazole compounds have been investigated theoretically. The gas and aqueous phase geometries, thermal and solvation free energies have been ... -
Rational design of cathode structure based on free-standing S/rGO/CNT nanocomposite for Li-S batteries
(Elsevier Science, 2020)Sulfur / reduced graphene oxide / carbon nanotube (S/rGO/CNT) composite cathodes were fabricated as laminar-structured free-standing papers to develop high-capacity lithium sulfur batteries (Li-S). Here, the rGO content ... -
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish
(Taylor & Francis Ltd, 2022)Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and ... -
The role of pharmacists in Kırklareli (Turkey) as primary health care providers
(University of Istanbul, 2017)This study was carried out in Kırklareli in 2005. The aim was to investigate the role of pharmacists as primary health care providers. In 63.5% of the total number of 55 pharmacies taking part in the research, there was ... -
Rosmarinus officinalis L. essential oil encapsulated in new microemulsion formulations for enhanced antimicrobial activity
(Wiley, 2022)In this present study, Rosmarinus officinalis essential oil and its new microemulsions (MEs) were evaluated both for the in vitro antibacterial and antifungal activity. The essential oil composition was verified initially ... -
Sağlık hukuku açısından farmakovijilans sistemi
(İstanbul Medipol Üniversitesi, 2021)Sağlık Hukuku, sağlığa ilişkin hukuki sorunlarla uğraşan multidisipliner bir bilim dalıdır. İnsan yaşamını ve sağlığını ilgilendiren her hukuki sorun, Sağlık Hukukunun çözüm araması gereken bir konudur. Hasta güvenliği, ... -
Sağlık öğrencilerinde aşı tereddüdü
(Hayat Sağlık ve Sosyal Hizmetler Vakfı, 2021)Amaç: Bu çalışmada İstanbul’da sağlık alanında (tıp, diş hekimliği, eczacılık, hemşirelik, ebelik, fizik tedavi ve rehabilitasyon, diyetisyenlik, odyoloji, sağlık yönetimi) yükseköğrenim görmekte olan öğrencilerin aşı ... -
Sambulin A and B, non-glycosidic iridoids from Sambucus ebulus, exert significant in vitro anti-inflammatory activity in LPS-induced RAW 264.7 macrophages via inhibition of MAPKs's phosphorylation
(Elsevier Irelan Ltd, 2017)Ethnopharmacological relevance: The leaves of Sambucus ebulus L. (Adoxaceae) are widely used in Turkish folk medicine particularly against inflammatory disorders. The fresh leaves after wilted over fire or the poultices ... -
Screening of antimicrobial, antioxidant, antidiabetic activities, anatomical and morphological properties of Colchicum speciosum Steven (Colchicaceae)
(Springer, 2022)Colchicum speciosum Steven species is a perennial stemless plant. C. speciosum is a flowering herb native to mountainous regions of northern Turkey, the Caucasus, and northern Iran. It has been known as "Vargit, Aci cigdem, ... -
Seminal trace elements and their relationship with sperm parameters
(Wiley, 2022)Male reproductive problems may derive from many reasons including the environmental toxicants which may either intaken by occupational exposure, nutrition or bad air quality. The increased exposure to these substances due ... -
Separate and mutual effects of BIRB796 and bortezomib on pHsp27 and viability of U87MG glioma cells
(Pleiades Publishing, 2023)Hsp27 phosphorylation is associated with many pathways in glioma, such as tumor cell proliferation and apoptosis inhibition. The aim of this study is to examine the separate and mutual effects of BIRB796 and bortezomib on ... -
Separation of gold(III) ions by 1,8-diaminonaphthalene-formaldehyde chelating polymer
(Elsevier Science Bv, 2013)In the present work, a new 1,8-diaminonaphthalene-formaldehyde (1,8-DAN-F) polymer was synthesized by the reaction of 1,8-DAN with formaldehyde solution. The structure of 1,8-DAN-F polymer was characterized by elemental ... -
Sesquiterpene coumarin ethers with selective cytotoxic activities from the roots of ferula huber-morathii Peşmen (Apiaceae) and unequivocal determination of the absolute stereochemistry of samarcandin
(MDPI, 2023)Ancient physicians frequently used the resin of Ferula species to treat cancer. Today, some folkloric recipes used for cancer treatment also contain the resin of Ferula species. The dichloromethane extract of the roots of ... -
Significance of a clinical pharmacist-led comprehensive medication management program for hospitalized oncology patients
(Springer, 2020)Background The use of highly toxic drugs in cancer treatment and supportive care medications exposes patients to an increased number of drug-related problems (DRPs). Clinical pharmacists contribute to the optimal use of ... -
A single center cohort of 40 severe COVID-19 patients who were treated with convalescent plasma
(Tübitak Scientific & Technical Research Council Turkey, 2020)Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was ... -
Sprayable microemulsion of diphenhydramine hydrochloride for dermal delivery
(2024)In this work, a sprayable microemulsion of diphenhydramine hydrochloride (DPH HCl) was developed for use in conditions that cause itching, such as insect bites, mild sunburns, and skin irritations. Microemulsions were ... -
Steam bath, vibration, and thermal ablation administrations augment the release of tramadol HCl from transdermal patch and enhance the plasma concentration in rats
(Marmara University, 2023)Recently, transdermal drug delivery has become popular due to their numerous advantages. They offer non-invasive application and eliminate the first-pass metabolism. The skin membrane is sensitive to heat and vibration ... -
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives
(Pergamon-Elsevier Science Ltd, 2018)Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their ...
