ORCID "0000-0001-6047-2796" Makale Koleksiyonu için listeleme
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Surgical orthopedic patients’ perception of antibiotic use and antibiotic resistance
Ahmetaj, Donjete; Aksoy, Nilay; Berk, Barkın (University of Ankara, 2023)Objective: The aim of the study was to evaluate orthopedic patients' knowledge of antibiotics and antibiotic resistance. Material and Method: Patients admitted to the hospital for orthopedic surgery were given a questionnaire ... -
Synthesis and antibacterial evaluation of novel benzimidazole, benzothiazole, benzofurane, and naphtofurane derivatives of aminothiazoles
Şahin, Zafer; Tok, Büşra Işıl; Akgün, Erol; Çaşkurlu, Ayşegül; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Ankara Association of Pharmaceutical Sciences, 2022)The thiazole ring is the core of bioactive molecules that generate broad activity. These activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In this work, starting from seconder/cyclic amines, ... -
Synthesis and in vitro antitumor activities of novel thioamide substituted piperazinyl-1,2,4-triazines
Şahin, Zafer; Biltekin, Sevde Nur; Ozansoy, Mehmet; Hemiş, Bervis; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Wiley, 2022)Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3-triazine, 1,3,5-triazine (s-triazine) and 1,2,4-triazine. All of these skeletons were ... -
Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds
Tay, Naime Funda; Berk, Barkın; Duran, Murat; Kayagil, İsmail; Yurttaş, Leyla; Biltekin Kaleli, Sevde Nur; Yamaç, Mustafa; Karaduman, Ayşe Betül; Demirayak, Şeref (Walter de Gruyter GmbH, 2022)In this study, novel 4-(5-((2/3/4-substituted benzyl)thio)-4-(4-substituted phenyl)-4H-1,2,4-triazol-3-yl)-2-(pyridin-3/4-yl)thiazoles were synthesized following a multi-step synthetic procedure. All the compounds were ... -
Synthesis, antimicrobial activity studies and molecular property predictions of schiff bases derived from ortho-vanillin
Berk, Barkın; Ertaş, Merve; Biltekin, Sevde Nur (University of Istanbul, 2017)Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antibacterial and antimalarial properties. At the same time, in recent years, prediction of drug-likeness, molecular, ... -
The synthesis, antimicrobial activity studies, and molecular property predictions of novel benzothiazole-2-thione derivatives
Berk, Barkın; Atlas Tahirovic, Yeşim; Bülbül, Emre Fatih; Biltekin, Sevde Nur (University of Istanbul, 2017)Benzothiazoles and 2-mercaptobenzothiazoles are important classes of bioactive organic scaffolds possessing antibacterial, antifungal, antitubercular, antiinflamma-tory, antidiabetic, and antimalarial properties. In recent ... -
Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles
Şahin, Zafer; Koçoğlu Kalkan, Melike; Berk, Barkın; Yurttaş, Leyla; Bender, Ceysu; Biltekin Kaleli, Sevde Nur; Demirayak, Şeref (Scientific Technical Research Council Turkey-Tubitak, 2021)Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives ... -
Thiazole-substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors
Şahin, Zafer; Ertaş, Merve; Bender, Ceysu; Bülbül, Emre Fatih; Berk, Barkın; Biltekin, Sevde Nur; Yurttaş, Leyla; Demirayak, Şeref (Wiley, 2018)Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE). Studies on Alzheimer's disease (AD) in the mid-20th century proved ...