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Occurrence of fumonisins B1 and B2 in homemade medicinal plants: Exposure assessment in Northern Turkey
(Akademiai Kiado Rt., 2016)This study was conducted to determine the recent level of contamination with Fumonisin B1 (FB1) and Fumonisin B2 (FB2) in major medicinal plants and to assess consumer exposure in northern Turkey. FB1 and FB2 were investigated ... -
Online-HPLC strategies, antioxidant and enzyme inhibitory activities of different extracts of mondia whitei leaves
(Biolife Sas, 2023)Background: Mondia whitei, an indigenous African plant, is widely recognised for its medicinal properties. Throughout ancient times, African communities have employed this remedy to address a wide range of health conditions. ... -
An optimization study on solid lipid nanoparticles using artificial neural network
(Colegio Farmaceuticos Provincia De Buenos Aires, 2017)Common use of supportive programs in finding the best in R&D studies provides positive results and thus ensures benefits to companies in terms of cost and time. The aim of this work was to develop, evaluate and optimize ... -
Opuntia ficus indica fruits ameliorate cisplatin-induced nephrotoxicity in mice
(Pharmaceutical Society of Japan, 2020)This study aims to determine the potential renal protective effects of Opuntia ficus-indica (L.) Miller (OFI) fruits against cisplatin-induced nephrotoxicity in mice. The antioxidant activity of OH methanol extract was ... -
Panax ginseng extract ameliorates methotrexate-induced multi-organ damage via the regulation of oxidative stress
(Marmara University, 2023)Oxidative damage plays an important role in organ toxicities caused by methotrexate (MTX). This study aimed to determine the antioxidant effects of Panax ginseng (PxG) extract against MTX-induced liver, lung, ileum and ... -
Phthalocyanine-conjugated glyconanoparticles for chemo-photodynamic combination therapy
(NLM (Medline), 2021)Combination cancer therapy based on multifunctional nanomaterials has attracted great attention. The present work focuses on the preparation of the glycopolymeric nanoparticle, which contains a photosensitizer (zinc(II)p ... -
Phytochemical analysis, antioxidant, and enzyme inhibition activity of five Salvia taxa from Turkey
(Elsevier B.V., 2023)Salvia L. species are widely used for treatment of different disorders in traditional Turkish medicine. In this study, the methanol extracts of five Salvia taxa, including S. aucheri subsp. canescens, S. aytachii, S. ... -
Phytochemical and in vitro pharmacological evaluation of Phlomis Pungens
(Ankara University, 2022)Objective: This study aimed to investigate the in vitro wound healing, anti-inflammatory, antimicrobial and antioxidant activity of Phlomis pungens Willd. extract derived from the aerial parts. Material and Method: The ... -
Phytochemical profile and antioxidant activity potential of Lotus sanguineus (Vural) D.D.Sokoloff
(Istanbul Medipol University, 2024)The in vitro antioxidant activity and phenol, phenolic acid, flavonoid, and proanthocyanidin content of Lotus sanguineus (Vural) D.D.Sokolof extracts were investigated. The aerial parts of Lotus sanguineus have high ... -
Phytochemical screening, biological evaluation, anatomical, and morphological investigation of Ferula tingitana L. (Apiaceae)
(Springer Wien, 2023)Ferula tingitana L. is a high perennial plant and its leaf is an alternate arrangement and yellow, and its flowers are unisexual like other Apiaceae. It has been used as a spice and for various medicinal purposes in the ... -
Platinum(II)-thiosemicarbazone drugs override the cell resistance due to glutathione; assessment of their activity against human adenocarcinoma cells
(Taylor & Francis Ltd, 2016)New platinum(II) compounds of the thiosemicarbazone 1-(1H-Benzimidazol-2-yl)ethan-1-one thiosemicarbazone (BzimetTSCH), [Pt(BzimetTSCH)Cl]center dot 2H(2)O (1) and [Pt(BzimetTSCH)(tpp)]Cl center dot H2O center dot MeCN (2) ... -
Potent colon cancer cell line toxicity of the fruit extracts of Heptaptera triquetra (Vent.) Tutin
(Istanbul Medipol University, 2022)Cytotoxic activities of the fruit extracts of Heptaptera triquetra (Vent.) Tutin were investigated on the colon cancer COLO205 and KM12 cell lines. The dichloromethane extract of the fruits of H. triquetra showed the highest ... -
Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives
(Wiley, 2019)The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal chemists. In addition, thiosemicarbazones are among the most potent and ... -
Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine
(Taylor & Francis Ltd, 2017)The purpose of the current research was to prepare and evaluate the potential use of microemulsion-based hydrogel (MBH) formulations for dermal delivery of benzocaine (BZN). The pseudoternary-phase diagrams were constructed ... -
Preparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment
(Marmara University, 2019)The aim of the study is to evaluate the strengthening of penetration of the epidermis through the formulas containing hydroquinone in melasma treatment and development of alternative new carrier systems. During preparation ... -
The prevalence of drug-drug interactions and reported therapy related side-effects in oncology out-patients
(Marmara University, 2023)Objective: The use of multiple medications in cancer patients is unavoidable; thus, adverse drug-drug interactions are frequent. This study aims to assess the prevalence of potential drug interactions in oncology patients ... -
Prognostic significance of tumor tissue NeuGcGM3 ganglioside expression in patients receiving racotumomab immunotherapy
(Hindawi Ltd., 2020)Expression ofN-glycolyl GM3 (NeuGcGM3) ganglioside was detected in the tumor specimens of patients who were on Racotumomab anti-idiotype vaccine maintenance treatment, and prognostic significance as a biomarker was ... -
A prospective study concerning the effect of pharmaceutical care services on patients with heart failure
(Marmara University, 2022)Objective: Heart failure (HF), caused by an abnormality in cardiac function, is the inability of heart tissue to pump blood or deliver sufficient oxygen, resulting in abnormal diastolic volume. Drug-Related Problems (DRPs) ... -
Protective effect of N-Acetyl-L-Cysteine (NAC) on endosulfan-induced liver and kidney toxicity in rats
(E-Century Publishing Corp, 2017)Endosulfan-induced systemic toxicity arises from oxidative stress and glutathione depletion. This study aims to investigate the possible protective effect of N-acetyl-L-cysteine (NAC) against endosulfan-induced toxicity ... -
Protective effects of momordica charantia (Bitter Melon) against metho-trexate-induced kidney damage
(Bentham Science Publishers, 2023)Background: Methotrexate is a cytotoxic chemotherapeutic agent that has severe side ef-fects, such as nephrotoxicity. Momordica charantia is a bright yellow-orange fruity plant that has been shown to have antioxidant, ...
