Bölüm "İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı" Makale Koleksiyonu için listeleme
Toplam kayıt 33, listelenen: 1-20
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Anti-inflammatory and anti-oxidant properties of Ipomoea nil (Linn.) Roth significantly alleviates cigarette smoke (CS)-induced acute lung injury via possibly inhibiting the NF-KB pathway
(Elsevier France, 2022)Acute respiratory distress syndrome (ARDS), a serious manifestation of acute lung injury (ALI), is a debilitating inflammatory lung disease that is caused by multiple risk factors. One of the primary causes that can lead ... -
Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites
(Frontiers Media S.A., 2022)Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ... -
Association of arbitrary prescribing behavior to costly drug expenditures: A pharmacoeconomic study in primary care
(Oxford University Press, 2024)Background: We aimed to examine the cost-related prescribing performance of primary care physicians who had a higher versus lower tendency of arbitrary prescribing. Methods: In this cross-sectional study, we evaluated the ... -
The association of chiral characteristic with drug withdrawal due to safety: A comparative analysis
(Wiley, 2023)Aims Chirality of drugs might be associated with safety issues through pharmacokinetic or pharmacodynamic variations, interactions, or direct toxicological responses. We aimed to compare chiral status of the available drugs ... -
Comparison of paracetamol and diclofenac prescribing preferences for adults in primary care
(Cambridge University Press, 2021)Introduction: The most frequently prescribed analgesic drugs in primary care centers in Turkey are diclofenac and paracetamol, respectively. In this study, we aimed to compare paracetamol-included prescriptions (PIP) and ... -
Comparison of pediatric antibiotic prescribing practice between low and high prescribers for children in primary care
(Turkish National Pediatric Society, 2022)Background. Antibiotic prescribing is more prevalent in children. Many factors influence this practice, including the burden of outpatient visits. We aimed to compare antibiotic prescribing for children by low prescribers ... -
Comparison of primary care prescriptions for old and very old hypertensive patients
(TÜBİTAK (Scientific and Technological Research Council of Türkiye), 2023)Background/aim: Elderly and very elderly individuals might be subject to different approaches for the treatment of hypertension. We aimed to compare drug utilization in hypertensive old patients and very old patients in ... -
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
(Elsevier Inc., 2022)Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ... -
Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents
(Elsevier, 2020)In drug-resistant phytopathogenic fungi, there has been extensive research on microbiological and antifungal drug development. In this study, a novel series of cylopentapyrazole bearing a 1,2,3-thiadiazole ring 2a-e were ... -
Determination of antioxidant, anticancer, antidiabetic and antimicrobial activities of Turkish red pine (Pinus brutia Ten.) bark ultrasound-assisted extract as a functional food additive
(Akademiai Kiado Zrt., 2023)Turkish red pine (Pinus brutia Ten.) is an important tree species that grows widely in Turkiye. In this study, Box-Behnken experimental design was created and optimised for ultrasound assisted extraction of bioactive ... -
Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
(Nature Research, 2022)Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease ... -
Drug utilization studies in Turkiye: A systematic review
(Kare Publishing, 2024)OBJECTIVE: Drug utilization studies (DUS) provide a framework for drug utilization at the national or targeted population level and important information on unmet medical needs, particularly in assessing the rationality ... -
An economical and practical procedure of favipiravir synthesis for the treatment of Covid-19
(Springer Science and Business Media Deutschland GmbH, 2023)Favipiravir is a wide-spectrum antiviral generic drug that has received large attention during the recent COVID-19 pandemic. While there are synthetic strategies for favipiravir synthesis, economical procedures could ... -
An efficient approach to access 2,5-disubstituted 1,3,4-oxadiazoles by oxidation of 2-arenoxybenzaldehyde N-acyl hydrazones with molecular iodine
(Wiley-VCH Verlag, 2022)An oxidative cyclization of 2-arenoxybenzaldehyde N-acyl hydrazones 3 a-o was employed to synthesize new 2,5-disubstituted 1,3,4-oxadiazole compounds 4 a-d, 4 f-i, 4 k-n. This method involves oxidative cyclization of ... -
Essential parameters and risk factors of the patients for diabetes care and treatment
(Elsevier Ltd, 2017)Aim: The aim was to explore the association between Type 2 Diabetes Mellitus [T2DM] treatment satisfactions of patients regarding their socio-economic, life-style, history medication and clinical outcome in a Turkish ... -
Good versus poor prescribers: The comparison of prescribing competencies in primary care
(Cambridge University Press, 2022)Aim: To compare the competencies of primary care physicians (PCPs) with poor and good prescribing performance in frequently encountered indications. Background: Primary care centers are one of the mostly visited health ... -
The impact of chiral switch on drug labeling in Turkey: Indication, posology, and adverse effects
(Marmara University, 2023)Objective: Chiral switch, which involves replacing racemic drugs to market them as pure enantiomers, is presumed to improve efficacy and safety. Data on how chiral switch-related changes are represented in summary of product ... -
Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2
(Wiley, 2022)Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on the literature, among these natural plants Artemisia annua L. shows some promise for the treatment ... -
Investigation of allergy management in primary care: Child vs. adult prescriptions
(2021)Objective: Allergic diseases are conditions that are frequently encountered in primary care, and different drug groups can be used in their treatment. This study aimed to compare the use of drugs in allergy in children and ... -
Knowledge, opinions and attitudes of primary care physicians about generic drugs: A cross-sectional study
(Oxford University Press, 2021)Background: Generic drug (GD) use is affected by many factors, including physicians' approach.Objective: This study aimed to investigate the knowledge, opinions and attitudes of primary care physicians (PCPs) about GDs and ...