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A homozygous TPO gene duplication (c. 1184_1187dup4) causes congenital hypothyroidism in three siblings born to a consanguineous family
(Georg Thieme Verlag, 2015)Congenital hypothyroidism (CH) is the most common neonatal endocrine disease, and germ-line mutations in the TPO gene cause the inherited form of the disease. Our aim in this study was to determine the genetic basis of ... -
Blood accessibility to fibrin in venous thrombosis is thrombus age-dependent and predicts fibrinolytic efficacy: An in vivo fibrin molecular imaging study
(Ivyspring International Publisher, 2015)Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent ... -
Guiding empiric treatment for serious bacterial infections via point of care beta-lactamase characterization
(Ieee-Inst Electrical Electronics Engineers Inc, 2016)Fever is one of the most common symptoms of illness in infants and represents a clinical challenge due to the potential for serious bacterial infection. As delayed treatment for these infections has been correlated with ... -
A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl
(Elsevier GmbH, 2016)Axolotl (Ambystoma Mexicanum) has been emerging as a promising model in stem cell and regeneration researches due to its exceptional regenerative capacity. Although it represents lifelong lasting neoteny, induction to ... -
Transcription factor 4 gene rs9960767 polymorphism in bipolar disorder
(Spandidos Publications, 2016)The transcription factor 4 (TCF4) gene encodes a helix-loop-helix transcription factor protein, which initiates neuronal differentiation and is primarily expressed during nervous system development. The aim of the present ... -
Association of Enteric Protist Blastocystis spp. and gut microbiota with hepatic encephalopathy
(Medical Univ Press, 2016)Background & Aims: Hepatic encephalopathy (HE) is a serious neuropsychiatric sequela emerging in the advanced stages of cirrhosis. The gut microbiota plays an important role in the development of HE. The aim of the study ... -
Aksolotl rejenerasyonunun farklı evrelerinde miRNA profilinin bulunması ve bulunan miRNA'ların görevlerinin in-siliko analizi
(2017)Giriş ve Amaç: Rejenerasyon, fonksiyonel bir kayıp yaşamadan hasarlı dokunun, organın ya da uzvun restore edilmesi işlemidir. Su semenderlerinden olan Aksolotl kendisini öldürmeyecek iç organ, merkezi sinir sistemi ve uzuv ... -
An assessment of reliability and validity of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 among breast cancer patients in Qatar
(Wolters Kluwer - Medknow, 2017)Introduction: Breast cancer has been the most common cancer type that affects women worldwide and subsequent treatment is oftenassociated with considerable psychological and quality of life (QoL). Aim: This study aimed to ... -
Assessing breast cancer risk estimates based on the gail model and its predictors in Qatari women
(Sage Publications Inc, 2017)Background: The Gail model is the most widely used breast cancer risk assessment tool. An accurate assessment of individual's breast cancer risk is very important for prevention of the disease and for the health care ... -
Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism
(Oxford University Press Inc, 2017)Context: The DUOX2 enzyme generates hydrogen peroxide (H2O2), a crucial electron acceptor for the thyroid peroxidase-catalyzed iodination and coupling reactions mediating thyroid hormone biosynthesis. DUOX2 mutations result ... -
Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo
(Oxford University Press, 2017)Aims Fibrin deposition and absent endothelium characterize unhealed stents that are at heightened risk of stent thrombosis. Optical coherence tomography (OCT) is increasingly used for assessing stent tissue coverage as a ... -
Increased long distance event-related gamma band connectivity in Alzheimer's disease
(Elsevier Science Ltd., 2017)Background: Brain oscillatory responses can be used for non-invasive analyses of cortico-cortical connectivity, local neuronal synchronization, and coherence of oscillations in many neuropsychiatric conditions including ... -
Examining pediatric cases from the clinical research office of the endourological society ureteroscopy global study
(Elsevier Science Inc, 2017)OBJECTIVE To evaluate the characteristics and outcomes of ureteroscopy (URS) in children treated in several hospitals participating in the Clinical Research Office of the Endourological Society (CROES) Study, and to present ... -
Driver sleepiness, fatigue, careless behavior and risk of motor vehicle crash and injury: Population based case and control study
(Elsevier Science Bv, 2017)Background: A few studies have been conducted to determine the relationship between road motor vehicle crashes (MVC) and serious injuries related to tiredness, fatigues and sleeping. Aim: To determine the effects of ... -
Efficient transgenesis and annotated genome sequence of the regenerative flatworm model Macrostomum lignano
(Nature Publishing Group, 2017)Regeneration-capable flatworms are informative research models to study the mechanisms of stem cell regulation, regeneration, and tissue patterning. However, the lack of transgenesis methods considerably hampers their wider ... -
A comparative study of fixatives for axolotl blastema tissue
(Soc Chilena Anatomia, 2017)Regeneration is defined as tissue renewal and functional restoration process of the damaged parts of the body after an injury. Ambystoma mexicanum, commonly named the Axolotl, is one of the unique vertebrates, which has a ... -
Essential parameters and risk factors of the patients for diabetes care and treatment
(Elsevier Ltd, 2017)Aim: The aim was to explore the association between Type 2 Diabetes Mellitus [T2DM] treatment satisfactions of patients regarding their socio-economic, life-style, history medication and clinical outcome in a Turkish ... -
Iron and Vitamin D levels among autism spectrum disorders children
(Medknow Publications and Media Pvt. Ltd., 2017)The aim of this study was to investigate iron deficiency anemia and Vitamin D deficiency among autism children and to assess the importance of risk factors (determinants). Subjects and Methods: This was a case-control study ... -
Detailed tail proteomic analysis of axolotl (Ambystoma mexicanum) using an mRNA-seq reference database
(Wiley, 2017)Salamander axolotl has been emerging as an important model for stem cell research due to its powerful regenerative capacity. Several advantages, such as the high capability of advanced tissue, organ, and appendages ... -
Skov-3 over kanseri hücre hattında fotodinamik terapi uygulaması
(2017)Sürdürülen sayısız araştırmaya ve geliştirilen ilaçlara rağmen günümüzde kanser hala milyonlarca insanın ölümüne neden olan hastalıkların başında gelmektedir. Over kanseri en ölümcül kanserlerden biri olup kadınlarda en ...