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Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
Gül, Şeref; Akyel, Yasemin Kübra; Gül, Zeynep Melis; Işın, Şafak; Özcan, Onur; Korkmaz, Tuba; Selvi, Saba; Danış, İbrahim; Şavluğ İpek, Özgecan; Aygenli, Fatih; Taşkın, Ali Cihan; Akarlar, Büşra Aytül; Özlü, Nurhan; Öztürk, Nuri; Öztürk, Narin; Özer Ünal, Durişehvar; Güzel, Mustafa; Türkay, Metin; Okyar, Alper; Kavaklı, İbrahim Halil (Nature Research, 2022)Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease ...