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Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
(Elsevier Sciences Bv, 2017)
Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ...
Poloxamer P85 increases anticancer activity of schiff base against prostate cancer in vitro and in vivo
(Lippincott Williams and Wilkins, 2017)
Prostate cancer is the second most common cancer among men and the leading cause of death after lung cancer. Development of hormone-refractory disease is a crucial step for prostate cancer progression for which an effective ...
Anticonvulsant activity of resveratrol-loaded liposomes in vivo
(Pergamon-Elsevier Science Ltd, 2017)
Resveratrol (3,5,4'-stilbenetriol), a natural polyphenol produced by various plants, has attracted attention over the past decade because of its multiple beneficial properties, including anti-inflammatory, anti-oxidant and ...
Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
(Medknow Publications & Media Pvt Ltd., 2017)
Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after ...