ORCID "0000-0001-7702-2441" Makale Koleksiyonu için listeleme
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Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappa b pathways in traumatic brain injury in mice
Çağlayan, Berrak; Kılıç, Ertuğrul; Dalay, Arman; Altunay, Serdar; Tuzcu, Mehmet; Erten, Füsun; Orhan, Cemal; Günal, Mehmet Yalçın; Yuluğ, Burak; Juturu, Vijaya; Şahin, Kazım (Springer, 2019)Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in young adults and children in the industrialized countries; however, there are presently no FDA approved therapies. TBI results in oxidative ... -
A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?
Günal, Mehmet Yalçın; Yuluğ, Burak; Çağlayan, Berrak; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Kılıç, Ertuğrul (Czech Medical Soc, 2019)Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ... -
Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
Keskin, İlknur; Günal, Mehmet Yalçın; Aytürk, Nilüfer; Kılıç, Ülkan; Ozansoy, Mehmet; Kılıç, Ertuğrul (Medknow Publications & Media Pvt Ltd., 2017)Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after ... -
Effects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing
Keskin, İlknur; Günal, Mehmet Yalçın; Ayla, Şule; Kolbaşı, Bircan; Sayın Şakul, Arzu Ayşe; Kılıç, Ülkan; Gök, Özlem; Köroğlu, Kutay M.; Özbek, Hanefi (Taylor and Francis Ltd, 2017)We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and ... -
The effects of topical carvacrol application on wound healing process in male rats
Günal, Mehmet Yalçın; Okçu Heper, Aylin; Zaloğlu, Nezahat (EManuscript Services, 2014)Carvacrol containing products such as Origanum onites have been used as phytotherapeutic agents in the treatment of serious skin injury. It has been suggested that carvacrol is the active component of these herbs because ... -
In vitro effects of rabeprazole on human pylorus tone
Yaşar, Necdet Fatih; Polat, Erdal; Duman, Mustafa; Dağdelen, Meltem; Günal, Mehmet Yalçın; Uzun, Orhan; Akyüz, Cebrail; Peker, Kıvanç Derya; Yol, Sinan (The Korean Society of Neurogastroenterlogy and Motility, 2015)Background/Aims It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus ... -
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Günal, Mehmet Yalçın; Çağlayan, Berrak; Yalçın, Esra; Keleştemur, Taha; Gündoğdu, Reyhan Zeynep; Yuluğ, Burak; Yılmaz, Bayram; Kerman, Bilal Ersen; Kılıç, Ertuğrul (Elsevier Sciences Bv, 2017)Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ... -
Pleiotropic and renoprotective effects of erythropoietin beta on experimental diabetic nephropathy model
Eren, Zehra; Günal, Mehmet Yalçın; Arı, Elif; Çoban, Jale; Çakalağaoğlu, Fulya; Çağlayan, Burak; Beker, Mustafa Çağlar; Akdeniz, Tuba; Yanıkkaya, Gülderen; Kılıç, Ertuğrul; Kantarcı, Gülçin (Karger, 2016)Background: This study aimed at investigating the possible protective effect of erythropoietin beta on experimental diabetic nephropathy (DN) model in rats. Methods: Sprague Dawley rats (n = 32) were allocated into 4 equal ... -
Protective effect of lutein/zeaxanthin isomers in traumatic brain injury in mice
Günal, Mehmet Yalçın; Şakul, Ayşe Arzu; Çağlayan, Ahmet Burak; Erten, Füsun; Durmaz Kurşun, Öznur Ece; Kılıç, Ertuğrul; Şahin, Kazım (Springer, 2021)Previous studies revealed that oxidative stress and inflammation are the main contributors to secondary injury after traumatic brain injury (TBI). In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert ... -
Role of erythropoietin and its receptor in the development of endometriosis in rats
Günal, Mehmet Yalçın; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Özdemir, Ekrem Musa; Aslan, İsmail; Eren, Zehra; Ersavaş, Cenk; Kılıç, Ertuğrul (Galenos Yayıncılık, 2019)Objective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial ... -
Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo
Doǧan, Ayşegül; Demirci, Selami; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Günal, Mehmet Yalçın; Uslu, Ünal; Cumbul, Alev; Şahin, Fikrettin (Humana Press, 2014)After a disruption of skin integrity, the body produces an immediate response followed by a functional and comparable regeneration period, referred to as wound healing. Although normal wounds do not need much attention ... -
Wound healing effects of methanol extract of Laurocerasus officinalis roem
Ayla, Şule; Okur, Mehmet Evren; Günal, Mehmet Yalçın; Özdemir, Ekrem Musa; Çiçek Polat, Derya; Yoltaş, Ayşegül; Biçeroğlu, Özge; Karahüseyinoğlu, Serçin (Taylor & Francis Ltd, 2019)Laurocerasus officinalis Roem. (syn: Prunus laurocerasus L.) is a member of Rosaceae family. We investigated the antimicrobial and antioxidant activity of L. officinalis Roem in wound healing both in vivo and in vitro using ...