ORCID "0000-0001-6494-8923" Makale Koleksiyonu için listeleme
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ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
Rohlfing, Anne-Katrin; Kolb, Kyra; Sigle, Manuel; Ziegler, Melanie; Bild, Alexander; Münzer, Patrick; Sudmann, Jessica; Dicenta, Valerie; Harm, Tobias; Manke, Mailin-Christin; Geue, Sascha; Kremser, Marcel; Chatterjee, Madhumita; Liang, Chunguang; Eysmondt, Hendrik von; Dandekar, Thomas; Heinzmann, David; Günter, Manina; Ungern-Sternberg, Saskia von; Büttcher, Manuela; Castor, Tatsiana; Mencl, Stine; Langhauser, Friederike; Sies, Katharina; Ashour, Diyaa; Beker, Mustafa Çağlar; Lämmerhofer, Michael; Autenrieth, Stella E.; Schäffer, Tilman E.; Laufer, Stefan; Szklanna, Paulina; Maguire, Patricia; Heikenwalder, Matthias; Müller, Karin Anne Lydia; Hermann, Dirk M.; Kılıç, Ertuğrul; Stumm, Ralf; Ramos, Gustavo; Kleinschnitz, Christoph; Borst, Oliver; Langer, Harald F.; Rath, Dominik; Gawaz, Meinrad (Nature Research, 2022)Platelet activation plays a critical role in thrombosis. Inhibition of platelet activation is a cornerstone in treatment of acute organ ischemia. Platelet ACKR3 surface expression is independently associated with all-cause ... -
Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Age-associated resilience against ischemic injury in mice exposed to transient middle cerebral artery occlusion
Beker, Mustafa Çağlar; Aydınlı, Fatmagül İlayda; Çağlayan, Ahmet Burak; Beker, Merve; Baygül, Oğuzhan; Çağlayan, Aysun; Popa-Wagner, Aurel; Doeppner, Thorsten R.; Hermann, Dirk M.; Kılıç, Ertuğrul (Springer, 2023)Ischemic stroke is the leading cause of death and disability. Although stroke mainly affects aged individuals, animal research is mostly one on young rodents. Here, we examined the development of ischemic injury in young ... -
Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappa b pathways in traumatic brain injury in mice
Çağlayan, Berrak; Kılıç, Ertuğrul; Dalay, Arman; Altunay, Serdar; Tuzcu, Mehmet; Erten, Füsun; Orhan, Cemal; Günal, Mehmet Yalçın; Yuluğ, Burak; Juturu, Vijaya; Şahin, Kazım (Springer, 2019)Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in young adults and children in the industrialized countries; however, there are presently no FDA approved therapies. TBI results in oxidative ... -
Anticonvulsant activity of resveratrol-loaded liposomes in vivo
Ethemoğlu, Muhsine Sinem; Şeker, Fatma Burcu; Akkaya, Hatice; Kılıç, Ertuğrul; Aslan, İsmail; Erdoğan, Cihan Süleyman; Yılmaz, Bayram (Pergamon-Elsevier Science Ltd, 2017)Resveratrol (3,5,4'-stilbenetriol), a natural polyphenol produced by various plants, has attracted attention over the past decade because of its multiple beneficial properties, including anti-inflammatory, anti-oxidant and ... -
The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
Yuluǧ, Burak; Saatçi, Özlem; Işıklar, Aysun; Hanoǧlu, Lütfü; Kılıç, Ülkan; Ozansoy, Mehmet; Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ertuğrul (Bentham Science Publ Ltd, 2020)Background and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer's Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an ... -
CCL11 differentially affects post-stroke brain injury and neuroregeneration in mice depending on age
Lieschke, Simone; Zechmeister, Bozena; Haupt, Matteo; Zheng, Xuan; Jin, Fengyan; Hein, Katharina; Weber, Martin S.; Hermann, Dirk M.; Bähr, Mathias; Kılıç, Ertuğrul; Doeppner, Thorsten R. (MDPI, 2020)CCL11 has recently been shown to differentially affect cell survival under various pathological conditions including stroke. Indeed, CCL11 promotes neuroregeneration in neonatal stroke mice. The impact of CCL11 on the adult ... -
Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition
Doeppner, Thorsten Roland; Kaltwasser, Britta; Schlechter, Jana; Jaschke, J.; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias; Weise, Jens (Nature Publishing Group, 2015)Although cellular prion protein (PrPc) has been suggested to have physiological roles in neurogenesis and angiogenesis, the pathophysiological relevance of both processes remain unknown. To elucidate the role of PrPc in ... -
Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice
Yuluğ, Burak; Kılıç, Ertuğrul; Altunay, Serdar; Ersavaş, Cenk; Orhan, Cemal; Dalay, Arman; Tuzcu, Mehmet; Şahin, Nurhan; Juturu, Vijaya; Şahin, Kazım (Bentham Science Publishers Ltd, 2018)Introduction: Cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for the treatment of different disease conditions which are associated with inflammation and oxidative stress. ... -
Delayed therapeutic administration of melatonin enhances neuronal survival through AKT and MAPK signaling pathways following focal brain ischemia in mice
Kılıç, Ülkan; Elibol, Birsen; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Beker, Merve; Altuğ Tasa, Burcugül; Uysal, Ömer; Yılmaz, Bayram; Kılıç, Ertuğrul (Springer Nature, 2022)Melatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed ... -
A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?
Günal, Mehmet Yalçın; Yuluğ, Burak; Çağlayan, Berrak; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Kılıç, Ertuğrul (Czech Medical Soc, 2019)Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ... -
Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
Keskin, İlknur; Günal, Mehmet Yalçın; Aytürk, Nilüfer; Kılıç, Ülkan; Ozansoy, Mehmet; Kılıç, Ertuğrul (Medknow Publications & Media Pvt Ltd., 2017)Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after ... -
The effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury
Diker, Nurettin; Çağlayan, Berrak; Helvacıoğlu, Fatma; Kılıç, Ertuğrul (Wiley, 2020)Axonal regeneration of the inferior alveolar nerve (IAN) is a therapeutic target for functional recovery after peripheral nerve injury. Rifampicin exerts anti-apoptotic, anti-inflammatory, and anti-oxidant effects on nerve ... -
Effects of erythropoietin on spontaneous and oxytocin induced myometrial contractions in the nonpregnant rat
Tuğ, Niyazi; Ayvacı Tasan, Habibe; Sargın, Mehmet Akif; Doğan Taymur, Bilge; Ayar, Ahmet; Kılıç, Ertuğrul; Yılmaz, Bayram (Verduci Publisher, 2017)OBJECTIVE: Erythropoietin (EPO) is a glycoprotein hormone that regulates erythropoiesis. EPO activity has also been detected in a variety of tissue including the nervous system, and female and male reproductive organs. It ... -
Effects of melatonin and 5-methoxytryptophol on synovial inflammation in the zymosan-induced rheumatoid arthritis in rats
Savtekin, Gökçe; Tuzum, Mustafa Şenol; Uyanık, Lokman Onur; Ayalı, Ayşa; Öğünç Velioğlu, Ayliz; Çetinel, Şule; Kılıç, Ertuğrul; Şehirli, Ahmet Özer (E-Century Publishing Corporation, 2016)The aim of this study is the investigation of synoviocytes, cytokines and metalloproteinases in the synovial inflammation model which is created by zymosan application to temporomandibular joint (TMJ) and effects of pineal ... -
Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups
Elibol, Birsen; Şahbaz, Çiğdem; Eyüboğlu, Siğnem; Çevreli, Burcu; Kılıç, Ülkan; Kılıç, Ertuğrul (Yerküre Tanıtım ve Yayıncılık Hizmetleri A.Ş., 2020)Objective: Herein, we aimed to investigate the long-term effects of neonatal hypoxia and the potential protective role of melatonin and memantine on the learning and memory. Methods: Seven-day-old rat underwent right carotid ... -
Effects of memantine and melatonin on signal transduction pathways vascular leakage and brain injury after focal cerebral ischemia in mice
Kılıç, Ülkan; Yılmaz, Bayram; Reiter, Rüssel; Yüksel, Adnan; Kılıç, Ertuğrul (Pergamon-Elsevier Science Ltd, 2013)Because of their favorable action profiles in humans, both memantine and melatonin are particularly interesting candidates as neuroprotectants in acute ischemic stroke. Until now, the signaling mechanisms mediating memantine's ... -
Effects of normobaric oxygen and melatonin on reperfusion injury: Role of cerebral microcirculation
Beker, Mustafa; Çağlayan, Ahmet Burak; Keleştemur, Taha; Çaǧlayan, Berrak; Yalçın, Esra; Yuluǧ, Burak; Kılıç, Ülkan; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Impact Journals, 2015)In order to protect the brain before an irreversible injury occurs, penumbral oxygenation is the primary goal of current acute ischemic stroke treatment. However, hyperoxia treatment remains controversial due to the risk ... -
Effects of paricalcitol and aliskiren combination therapy on experimental diabetic nephropathy model in rats
Eren, Zehra; Günal, Mehmet Yalçın; Arı Bakır, Elif; Çoban, Jale; Çaglayan, Berrak; Ekimci, Nur; Ethemoğlu, Sinem; Albayrak, Özgür; Akdeniz, Tuba; Yanıkkaya Demirel, Gülderen; Kılıç, Ertugrul; Kantarcı, Gülçin (Karger, 2014)Background/Aims: The aim of the present study was to investigate the effect of combination of aliskiren with paricalcitol on experimental diabetic nephropathy (DN) model in rats. Methods: Forty male Sprague Dawley rats ...