ORCID "0000-0003-0128-6947" Makale Koleksiyonu için listeleme
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Abortifacient effect of decreased decidual and placental galectin-1 expression due to metoclopramide exposure in pregnant rats
Çekmez, Yasemin; Korkmaz, Vakkaş; Çakır, Aslı; Göçmen, Ahmet; Ergün, Yusuf; Gülşen, Serdar (Journal of Reproductive Medicine, Inc., 2017)OBJECTIVE: To investigate the abortifacient effect of metoclopramide on decidual and trophoblastic tissues with immunohistochemical investigation of galectin-1 expression in pregnant rats. STUDY DESIGN: A total of 24 ... -
Acute temozolomide induced liver injury: Mixed type hepatocellular and cholestatic toxicity
Aygün, Cem; Yıldırım Altınok, Ayşe; Çakır, Aslı; Ağan, Ahmet Faruk; Balaban, Yasemin (Universa Press, 2016)Temozolomide (TMZ) is an oral imidazotetrazine methylating agent which is used for the treatment of glioblastoma multiforme (GBM). We report a case of acute hepatotoxicity in a 53-year old male patient after administration ... -
Acute temozolomide induced liver injury: Mixed type hepatocellular and cholestatic toxicity
Aygün, Cem; Yıldırım Altınok, Ayşe; Çakır, Aslı; Ağan, Ahmet Faruk; Balaban, Yasemin (Universa Press, 2016)Temozolomide (TMZ) is an oral imidazotetrazine methylating agent which is used for the treatment of glioblastoma multiforme (GBM). We report a case of acute hepatotoxicity in a 53-year old male patient after administration ... -
An animal model of effects of nicotine exposure on endometrial receptivity and embryo implantation in pregnancy
Akpak, Yaşam Kemal; Çekmez, Yasemin; Erdoğan Çakır, Aslı; Karaca, Nilay; Batmaz, Gonca; Gülşen, Serdar; Haberal, Esra Tuştaş (Taylor & Francis Ltd, 2017)Objective: This study aims at evaluating the endometrial receptivity in uterus of pregnant rats exposed to nicotine via examination of integrin expression by immunohistochemical effect. Methods: In this study, 16 healthy ... -
Arthroscopic excision of tendinous giant cell tumors causing locking in the knee joint
Gülenç, Barış; Kuyucu, Ersin; Yalçın, Sercan; Erdoğan Çakır, Aslı; Bülbül, Ahmet Murat (Galen S.R.O., 2018)PURPOSE OF THE STUDY Non-osseous giant cell tumors are locally aggressive tumors arising around joints. They are commonly located around synovial joints such as wrist and knee and occasionally cause mechanical symptoms. ... -
Artificial intelligence assistance significantly improves Gleason grading of prostate biopsies by pathologists
Bulten, Wouter; Balkenhol, Maschenka; Belinga, Jean-Joel Awoumou; Brilhante, Americo; Çakır, Aslı; Egevad, Lars; Eklund, Martin; Farre, Xavier; Geronatsiou, Katerina; Molinie, Vincent; Pereira, Guilherme; Roy, Paromita; Saile, Gunter; Salles, Paulo; Schaafsma, Ewout; Tschui, Joelle; Vos, Anne-Marie; van Boven, Hester; Vink, Robert; van der Laak, Jeroen; Hulsbergen-van der Kaa, Christina; Litjens, Geert (Springer Nature, 2021)The Gleason score is the most important prognostic marker for prostate cancer patients, but it suffers from significant observer variability. Artificial intelligence (AI) systems based on deep learning can achieve ... -
Artificial intelligence for diagnosis and Gleason grading of prostate cancer: The PANDA challenge
Bulten, Wouter; Kartasalo, Kimmo; Chen, Po-Hsuan Cameron; Ström, Peter; Pinckaers, Hans; Nagpal, Kunal; Cai, Yuannan; Steiner, David F.; van Boven, Hester; Vink, Robert; Hulsbergen-van de Kaa, Christina; van der Laak, Jeroen; Amin, Mahul B.; Evans, Andrew J.; van der Kwast, Theodorus; Allan, Robert; Humphrey, Peter A.; Grönberg, Henrik; Samaratunga, Hemamali; Delahunt, Brett; Tsuzuki, Toyonori; Häkkinen, Tomi; Egevad, Lars; Demkin, Maggie; Dane, Sohier; Tan, Fraser; Valkonen, Masi; Corrado, Greg S.; Peng, Lily; Mermel, Craig H.; Ruusuvuori, Pekka; Litjens, Geert; Eklund, Martin; Brilhante, Américo; Çakır, Aslı; Farré, Xavier; Geronatsiou, Katerina; Molinié, Vincent; Pereira, Guilherme; Roy, Paromita; Saile, Günter; Salles, Paulo G. O.; Schaafsma, Ewout; Tschui, Joëlle; Billoch-Lima, Jorge; Pereira, Emíio M.; Zhou, Ming; He, Shujun; Song, Sejun; Sun, Qing; Yoshihara, Hiroshi; Yamaguchi, Taiki; Ono, Kosaku; Shen, Tao; Ji, Jianyi; Roussel, Arnaud; Zhou, Kairong; Chai, Tianrui; Weng, Nina; Grechka, Dmitry (Nature Research, 2022)Through a community-driven competition, the PANDA challenge provides a curated diverse dataset and a catalog of models for prostate cancer pathology, and represents a blueprint for evaluating AI algorithms in digital ... -
Automated scoring of CerbB2/HER2 receptors using histogram based analysis of immunohistochemistry breast cancer tissue images
Kabakçı, Kaan Aykut; Çakır, Aslı; Türkmen, İlknur; Töreyin, Behçet Uğur; Çapar, Abdulkerim (Elsevier Ltd, 2021)Background and Objective: Visual expression of invasive breast cancer with immunohistochemistry (IHC) allows evaluation of CerbB2 receptors, such that CerbB2 mutated breast carcinomas are suitable for targeted therapy. ... -
Chordoid meningioma: Report of 5 cases and review of the literature
Tahta, Alican; Genç, Berkhan; Çakır, Aslı; Şekerci, Zeki (Taylor & Francis Ltd, 2023)Chordoid meningioma is a rare, more aggressive subtype of meningioma. This study documents the histological, radiological and clinical features of seven tumours in five patients among 131 meningioma patients who were treated ... -
Clinicopathological significance of insulin-like growth factor-1 receptor expression in breast cancer
Şahin, Sevinç; Çakır, Aslı; Gönül, İpek Işık; Seçkin, Selda; Uluoğlu, Ömer (Edizioni Luigi Pozzi, 2020)OBJECTIVE: Insulin-like growth factor 1 receptor (IGF1R) is a receptor protein tyrosine kinase that is claimed to be related with tumor development and progression of breast cancer with some conflicting results in the ... -
Clinicopathological significance of the proliferation markers Ki67, RacGAP1, and topoisomerase 2 alpha in breast cancer
Şahin, Sevinç; Işık Gönül, İpek; Çakır, Aslı; Seçkin, Selda; Uluoğlu, Ömer (Sage Publications Inc, 2016)Objectives. The aims of this study are to evaluate expressions of Ki67, RacGAP1 (MgcRacGAP) and topoisomerase 2 alpha (TOP2a), the markers related with cell proliferation that have been proposed to affect the prognosis in ... -
Comparison of pathological indexes (Ki-67, p53), and perfusion/diffusion mr parameters in glioma staging
Ertan, Gülhan; Ulus, Sıla; Erdoğan Çakır, Aslı (Duzce University Medical School, 2018)Aim: In this study, we aim to determine the diffusion characteristics of grade II astrocytomas and glioblastomas (GBM), and to determine the ability of apparent diffusion coefficient (ADC), relative cerebral blood volume ... -
Concordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastases
Batur, Şebnem; Dülger, Onur; Durak, Şermin; Yumuk, Perran Fulden; Çağlar, Hale Başak; Bozkurtlar, Emine; Bozkurt, Süheyla; Taştekin, Ebru; Çiçin, İrfan; Ahiskalı, Rengin; Çakır, Aslı; Öz, Büge (2020)Programmed death-ligand 1 (PD-L1) is suggested to be a predictive biomarker in non-small-cell lung carcinoma (NSCLC). However, the differential expression of PD-L1 in primary lung tumor vs. synchronous metastases, especially ... -
Discoid lupus erythematosus at the site of healed herpes zoster: Wolf's isotopic response: Case report
Balevi, Ali; Yüksel, Mavişe; Tavlı,Yeliz; Çakır, Aslı; Özdemir, Mustafa (Turkiye Klinikleri, 2013)The term Wolf's isotopic response refers to the appearance of a new skin disease at the site of an already healed, unrelated disease. In most cases, the initial disease is herpes zoster. Different diseases may subsequently ... -
Does gabapentin affect neural tube development? Experimental study using an early stage chick embryo model
Çetinkal, Ahmet; Çakır, Aslı (Turkish Neurosurgical Society, 2021)AIM: To determine whether using gabapentin (GBP), especially in the first maternal trimester, would affect the neural tube development of embryos in an early stage chick embryo (ESCE) model. MATERIAL and METHODS: One ... -
Does metoclopramide exposure alter endometrial receptivity and decrease pregnancy rates?
Çekmez, Yasemin; Korkmaz, Vakkas; Çakır, Aslı; Göçmen, Ahmet; Ergün, Yusuf; Gülşen, Serdar; Akpak, Yaşam Kemal (Taylor & Francis Ltd, 2016)Objective: The aim of this study was to investigate the effect of metoclopramide on endometrial receptivity with an immunohistochemical investigation of integrin beta 3 expression in pregnant rats. Materials and methods: ... -
Effect of a moustache on nasal Staphylococcus aureus colonisation and nasal cytology results in men
Soylu, Erkan; Orhan, İsrafil; Erdoğan Çakır, Aslı; İstanbullu, Ayşe; Altın, Gökhan; Yılmazer, Rasim; Çalım, Ömer Faruk (Cambridge University Press, 2015)Objective: This study compared the results of nasal Staphylococcus aureus carriage and nasal cytology in men with and without a moustache. Methods: The study group comprised 118 adult men with a moustache, and the control ... -
Effects of nicotine exposure on clomiphene citrate induced rats: Morphological and immunohistochemical analysis in the ovaries
Karaca, Nilay; Akpak, Yaşam Kemal; Erdoğan Çakır, Aslı; Maraşlı, Mustafa; Aktün, Hale Lebriz (S.O.G. Canada Inc., 2019)Objective: The most common use of ovulation induction in clomiphene citrate (CC) administered rats is to investigate whether there is any morphologically and immunohistochemically difference in nicotine exposure between ... -
Emerin expression in well differentiated epithelial lesions of thyroid: Implications in papillary thyroid carcinoma diagnosis and predicting malignant behavior
Çoban, İpek; Erdoğan Çakır, Aslı; Kökenek Ünal, Tuba Dilay; Başsüllü, Nuray; Karpuz, Vildan; Bülbül Doǧusoy, Gülen; Alper, Murat (Springer, 2015)Recently, it has been reported that identifying nuclear membrane irregularities with anti-emerin antibody is useful for papillary thyroid carcinoma diagnosis. However, literature regarding the significance of emerin ... -
Evaluating the features of interdigital neuroma using 3-Tesla magnetic resonance imaging
Örmeci, Tuğrul; Güler, Olcay; Malkoç, Melih; Kaya, Nurullah; İşyar, Mehmet; Çakır, Aslı; Şen, Selva; Mahiroğulları, Mahir (Sociedad Anatómica Española, 2023)Interdigital neuroma is an entrapment neurop-athy of the interdigital nerve. Previously, studies on interdigital neuroma were done with 1 Tesla Magnetic Resonance Imaging and more often 1.5 Tesla Magnetic Resonance Imaging. ...