Abortifacient effect of decreased decidual and placental galectin-1 expression due to metoclopramide exposure in pregnant rats
Künye
Çekmez, Y., Korkmaz, V., Çakır, A., Göçmen, A., Ergün, Y. ve Gülşen, S. (2017). Abortifacient effect of decreased decidual and placental galectin-1 expression due to metoclopramide exposure in pregnant rats. Journal of Reproductive Medicine, 62(4), 427-431.Özet
OBJECTIVE: To investigate the abortifacient effect of metoclopramide on decidual and trophoblastic tissues with immunohistochemical investigation of galectin-1 expression in pregnant rats. STUDY DESIGN: A total of 24 pregnant rats were selected for the study and divided into 3 groups as untreated, low-dose (1 mg/kg) metoclopramide applied, and high-dose (3 mg/kg) metoclopramide applied from days 5-15 of pregnancy. All rats were laparotomized on day 19 of pregnancy, and number of implantation sites, resorption, and dead or alive fetuses were recorded for evaluating abortifacient activity. Galectin-1 expression was investigated from decidual and trophoblastic tissues via immunohistochemical staining. RESULTS: The mean percentage of abortion was detected higher in the high-dose group than both control and low-dose groups. Galectin-1 staining was more intense and universal in the untreated group than both high- and low-dose metoclopramide exposed groups in labyrinth trophoblasts and decidual tissue. CONCLUSION: Metoclopramide exposure, especially in high doses, may cause abortion, and this drug should be recommended for use during pregnancy only when the benefit outweighs the risk.
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Journal of Reproductive MedicineCilt
62Sayı
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