dc.contributor.author | Çekmez, Yasemin | |
dc.contributor.author | Korkmaz, Vakkaş | |
dc.contributor.author | Çakır, Aslı | |
dc.contributor.author | Göçmen, Ahmet | |
dc.contributor.author | Ergün, Yusuf | |
dc.contributor.author | Gülşen, Serdar | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:35:25Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:35:25Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Çekmez, Y., Korkmaz, V., Çakır, A., Göçmen, A., Ergün, Y. ve Gülşen, S. (2017). Abortifacient effect of decreased decidual and placental galectin-1 expression due to metoclopramide exposure in pregnant rats. Journal of Reproductive Medicine, 62(4), 427-431. | en_US |
dc.identifier.issn | 0024-7758 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/770 | |
dc.description.abstract | OBJECTIVE: To investigate the abortifacient effect of metoclopramide on decidual and trophoblastic tissues with immunohistochemical investigation of galectin-1 expression in pregnant rats. STUDY DESIGN: A total of 24 pregnant rats were selected for the study and divided into 3 groups as untreated, low-dose (1 mg/kg) metoclopramide applied, and high-dose (3 mg/kg) metoclopramide applied from days 5-15 of pregnancy. All rats were laparotomized on day 19 of pregnancy, and number of implantation sites, resorption, and dead or alive fetuses were recorded for evaluating abortifacient activity. Galectin-1 expression was investigated from decidual and trophoblastic tissues via immunohistochemical staining. RESULTS: The mean percentage of abortion was detected higher in the high-dose group than both control and low-dose groups. Galectin-1 staining was more intense and universal in the untreated group than both high- and low-dose metoclopramide exposed groups in labyrinth trophoblasts and decidual tissue. CONCLUSION: Metoclopramide exposure, especially in high doses, may cause abortion, and this drug should be recommended for use during pregnancy only when the benefit outweighs the risk. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Journal of Reproductive Medicine, Inc. | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Abnormalities | en_US |
dc.subject | Abortifacient Agents | en_US |
dc.subject | Abortifacients | en_US |
dc.subject | Abortion | en_US |
dc.subject | Antiemetics/Adverse Effects | en_US |
dc.subject | Decidua | en_US |
dc.subject | Drug-Induced/Epidemiology | en_US |
dc.subject | Fetal Death/Chemically Induced | en_US |
dc.subject | Galectin-1 | en_US |
dc.subject | Metoclopramide | en_US |
dc.subject | Metoclopramide/Adverse Effects | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Teratogens | en_US |
dc.subject | Trophoblasts | en_US |
dc.title | Abortifacient effect of decreased decidual and placental galectin-1 expression due to metoclopramide exposure in pregnant rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Reproductive Medicine | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-0128-6947 | en_US |
dc.identifier.volume | 62 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 427 | en_US |
dc.identifier.endpage | 431 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |