ORCID "0000-0002-8084-7855" Makale Koleksiyonu için listeleme
-
Anti-inflammatory and hypoglycemic activities of alpha-pinene
Özbek, Hanefi; Yılmaz, Betül Sever (University of Istanbul, 2017)The aim of this study is to investigate the anti-inflammatory and hypoglycemic activities of alpha-pinene, and to find the median lethal dose (LD50) level in mice. Lethal dose levels of alpha-pinene were investigated using ... -
Antidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic mice
Özbek, Hanefi; Bahadır Acıkara, Özlem; Öz, Burçin Ergene; Özbilgin, Serkan; Kırmızı, Neriman İpek; Özrenk, Bade Cevriye; Tekin, Mehmet; Saltan, Gülçin (Faculdade de Ciencias Farmaceuticas (Biblioteca), 2019)In the current study, four Onobrychis species, O. albiflora Hub.-Mor., O. argyrea Boiss. subsp. argyrea Boiss., O. galegifolia Boiss., and O. tournefortii (Willd.) Desv. were collected from Anatolia to be evaluated for ... -
Antiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells
Bülbül, Muhammet Volkan; Özbek, Hanefi; Bahadır Acıkara, Özlem; Özbilgin, Serkan; Ergene Öz, Burçin; Kurtul, Ekin; Keskin, İlknur (Ondokuz Mayıs University, 2018)In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis ... -
Are intervertebral disc tissue cells damaged when attempting to prevent thrombus formation using dabigatran, a new oral anticoagulant?
Kaplan, Necati; Karaaslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Akgün, Feride Sinem; Çalışkan, Tezcan; Şimşek, Abdullah Talha; Özbek, Hanefi (Turkish Neurosurgical Society, 2019)AIM: To investigate the effect of dabigatran, a new oral anticoagulant, on human primary cell cultures isolated from intact intervertebral disc tissue. MATERIAL and METHODS: Cell cultures were prepared from tissues obtained ... -
Are radio-contrast agents commonly used in discography toxic to the intact intervertebral disc tissue cells?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Kaplan, Necati; Çalışkan, Tezcan; Özdemir, Çiğdem; Akyuva, Yener; Ateş, Özkan (Wiley, 2019)In the literature, there have been no studies showing clear results on how radio-contrast pharmaceuticals would affect intact disc tissue cells. In this context, it was aimed to evaluate the effects of iopromide and gadoxetic ... -
Are specific gene expressions of extracellular matrix and nucleus pulposus affected by primary cell cultures prepared from intact or degenerative intervertebral disc tissues?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Kaplan, Necati; Akyuva, Yener; Gönültaş, Aylin; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To determine the gene expression patterns of nucleus pulposus (NP) in cell cultures obtained from degenerated or intact tissues. MATERIAL and METHODS: Whereas 12 of the cases were diagnosed with lumbar disc herniation ... -
Delivering growth factors through a polymeric scaffold to cell cultures containing both nucleus pulposus and annulus fibrosus
Akyuva, Yener; Kaplan, Necati; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Karaaslan, Numan; Güler, Olcay; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth factor 1 (IGF-1) /bone morphogenetic protein (BMP)-2 following intervertebral disc ... -
Does nimodipine, a selective calcium channel blocker, impair chondrocyte proliferation or damage extracellular matrix structures?
Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Kaya, Yasin Emre; Yaşar, Şirin, Duygu; Özbek, Hanefi (Bentham Science Publishers, 2019)Background: The study aimed to investigate the effects of the active ingredient, nimodipine, on chondrocyte proliferation and extracellular matrix (ECM) structures in cartilage tissue cells. Methods: Chondrocyte cultures ... -
Does the energy restriction intermittent fasting diet alleviate metabolic syndrome biomarkers? A randomized controlled trial
Ergül Kunduracı, Yasemin; Özbek, Hanefi (MDPI, 2020)The aim of this study was to determine the efficacy of an energy restriction intermittent fasting diet in metabolic biomarkers and weight management among adults with metabolic syndrome. This randomized controlled study ... -
Does transcription factor, induced by daptomycin and vancomycin, affect HIF-1α, Chondroadherin, and COL2A1?
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaya, Yasin Emre; Akyuva, Yener; Kaplan, Necati; Doğan, Mustafa; Gümüştaş, Seyit Ali; Ateş, Özkan; Erdem, İlknur (Inonu University School of Medicine, 2018)Aim: In this study, it was firstly aimed to investigate the effect of Daptomycin (DAP) on the proliferation in Vancomycin (VCM)-administered primary chondrocyte cultures and non-drug-administered primary chondrocyte cultures. ... -
The effect of music therapy on the physical and mental parameters of cancer patients during hematopoietic stem cell transplantation
Geyik, Gizem İlayda; Doğan, Sibel; Özbek, Hanefi; Atayoğlu, Ali Timuçin (Wiley, 2021)Purpose Music therapy has been used for relaxation in traditional medicine. This study explored the effect of music therapy on the physical and mental parameters of cancer patients during hematopoietic stem cell transplantation ... -
Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue
Karaarslan, Numan; Batmaz, Ahmet Güray; Yılmaz, İbrahim; Özbek, Hanefi; Çalışkan, Tezcan; Yaşar Şirin, Duygu; Kaplan, Necati; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)Non-steroidal anti-inflammatory drugs (NSAIDs) that are applied through oral, injectable or topical routes have been widely used in painful and inflammatory musculoskeletal diseases. The current study aimed to determine ... -
Effect of radiation dose reduction on image quality in adult head CT with noise-suppressing reconstruction system with a 256 slice MDCT
Başkan, Özdil; Erol, Cengiz; Özbek, Hanefí; Paksoy, Yahya (Multimed, 2015)The purpose of our study was to investigate the effect of iterative reconstruction (IR) as a dose reduction system on the image quality (IQ) of the adult head computed tomography (CT) at various low-dose levels, and to ... -
Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue
Çalışkan, Tezcan; Şirin, Duygu Yaşar; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Akyuva, Yener; Kaplan, Necati; Kaya, Yasin Emre; Şimşek, Abdullah Talha; Güzelant, Aliye Yıldırım; Ateş, Özkan (Spandidos Publications, 2019)The aim of the present study was to investigate the effects of etanercept (ETA), a tumor necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral disc tissue. ETA is used as a treatment ... -
Effects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing
Keskin, İlknur; Günal, Mehmet Yalçın; Ayla, Şule; Kolbaşı, Bircan; Sayın Şakul, Arzu Ayşe; Kılıç, Ülkan; Gök, Özlem; Köroğlu, Kutay M.; Özbek, Hanefi (Taylor and Francis Ltd, 2017)We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and ... -
Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis
Özbek, Hanefi; Bahadır Acıkara, Özlem; Keskin, İlknur; Kırmızı, Neriman İpek; Özbilgin, Serkan; Öz Ergene, Burçin; Kurtul, Ekin; Özrenk, Bade Cevriye; Tekin, Mehmet; Saltan, Gülçin (Elsevier Masson SAS, 2017)Alchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced ... -
Evaluation of the antidiabetic activity of Alchemilla persica Rothm. In mice with diabetes induced by alloxan
Özbilgin, Serkan; Özbek, Hanefi; Kırmızı, Neriman İpek; Ergene Öz, Burçin; Kurtul, Ekin; Özrenk, Bade Cevriye; Saltan İşcan, Gülçin; Bahadır Acıkara, Özlem (Turkish Pharmacists Association, 2019)Objectives: Alchemilla species are used in Turkish folk medicine for the treatment of many diseases together with diabetes. Alchemilla persica, belonging to this genus, is widely distributed in Eastern Anatolia as well as ... -
Evaluation of the antidiabetic property of capparis ovata desf. Var. Palaestina zoh. Extracts using in vivo and in vitro approaches
Okur, Mehmet Evren; Çiçek Polat, Derya; Özbek, Hanefi; Yılmaz, Sezen; Yoltaş, Ayşegül; Arslan, Rana (Bentham Science Publ Ltd, 2018)Background and Objective: This paper is focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. Methods: Alloxan-induced ... -
Evaluation of the effect of apixaban on the primary intact intervertebral disc cell cultures
Akgün, Feride Sinem; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Şimşek, Abdullah Talha; Kaplan, Necati; Ateş, Özkan (2019)Aim: Apixaban is a frequently preferred pharmacological agent in clinics to prevent deep vein thrombosis and pulmonary embolism.Such new oral anticoagulants may cause hemorrhage’s in tissues and/or organs or may cause ... -
Evaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissue
Kaplan, Necati; Yılmaz, İbrahim; Karaaslan, Numan; Yaşar Şirin, Duygu; Şimşek, Abdullah Talha; Çalışkan, Tezcan; Bircan, Rıfat; Özbek, Hanefi (Turkish Neurosurgical Society, 2019)AIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral disc tissue cells. MATERIAL and METHODS: Primary cell cultures were established using ...