Anti-inflammatory and hypoglycemic activities of alpha-pinene
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CitationÖzbek, H. ve Yılmaz, B. S. (2017). Anti-inflammatory and hypoglycemic activities of alpha-pinene. Acta Pharmaceutica Sciencia, 55(4), 7-14. https://dx.doi.org/10.23893/1307-2080.APS.05522
The aim of this study is to investigate the anti-inflammatory and hypoglycemic activities of alpha-pinene, and to find the median lethal dose (LD50) level in mice. Lethal dose levels of alpha-pinene were investigated using a probit analysis method. For the anti-inflammatory activity measurement seven different groups were established and alpha-pinene was administered in four different doses: 0.05, 0.10, 0.25 and 0.50 mL/kg. For the evaluation of hypoglycemic activity six different groups, consisting of diabetic and healthy mice, were established. The strongest anti-inflammatory activity of alpha-pinene was observed with a 0.50 mL/kg dosage. The median effective dose (ED50) value of alpha-pinene was found to be 0.039 mL/kg. In diabetic mice ?-pinene showed significant levels of hypoglycemic activity at the 2nd and 24th hours. LD50 level of ?-pinene was determined to be 2.076 mL/kg. As a result, we conclude that alpha-pinene is a molecule that displays hypoglycemic and anti-inflammatory activities.