ORCID "0000-0001-9434-3861" Biomedical Engineering için listeleme
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Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites
İşlek, Zeynep; Üçışık, Mehmet Hikmet; Keskin, Elif; Onur Sucu, Bilgesu; Gomes-Alves, Ana G.; Tomás, Ana M.; Güzel, Mustafa; Şahin, Fikrettin (Frontiers Media S.A., 2022)Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ... -
Curcumin- and Piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of Curcumin on HCT116 colorectal cancer model
Bolat, Zeynep Büşra; İşlek, Zeynep; Demir, Bilun Nas; Yılmaz, Elif Nur; Şahin, Fikrettin; Üçışık, Mehmet Hikmet (Frontiers in Bioengineering and Biotechnology, 2020)Combination chemotherapy, administrating two chemotherapeutic agents concurrently, comes into prominence, as the heterogeneity or the level of the disease necessitates a collaborative action. Curcumin, isolated from turmeric, ... -
Cytotoxicity of standardized curcuminoids mixture against epithelial ovarian cancer cell line SKOV-3
Almosa, Heba; Alqriqri, Mihal; Denetiu, Iuliana; Baghdadi, Mohammed Abbas; Alkhaled, Mohammed; Alhosin, Mahmoud; Aldajani, Wejdan A.; Zamzami, Mazin; Üçışık, Mehmet Hikmet (MDPI, 2020)Herbal medicine has been in use for centuries for a wide variety of ailments; however, the efficacy of its therapeutic agents in modern medicine is currently being studied. Curcuminoids are an example of natural agents, ... -
Delivery of curcumin within emulsome nanoparticles enhances the anti-cancer activity in androgen-dependent prostate cancer cell
Bolat, Zeynep Büşra; İşlek, Zeynep; Şahin, Fikrettin; Üçışık, Mehmet Hikmet (Springer, 2023)Background: Curcumin, a dietary polyphenol isolated from turmeric, is a potent phytochemical possessing intrinsic anticancer activities against various cancer types including prostate cancer. However, low water solubility ... -
Emulsomes meet s-layer proteins: An emerging targeted drug delivery system
Üçışık, Mehmet Hikmet; Sleytr, Uwe Bernd; Schuster, Bernhard (Bentham Science Publishers, 2015)Here, the use of emulsomes as a drug delivery system is reviewed and compared with other similar lipidic nanoformulations. In particular, we look at surface modification of emulsomes using S-layer proteins, which are ... -
Neuroprotective effects of curcumin-loaded emulsomes in a laser axotomy-induced CNS injury model
Yılmaz, Elif Nur; Bay, Sadık; Öztürk, Gürkan; Uçışık, Mehmet Hikmet (Dove Medical Press Ltd, 2020)Purpose: Curcumin, a polyphenol isolated from the rhizomes of turmeric, holds great potential as a neuroprotective agent in addition to its anti-inflammatory and antioxidant characteristics. The poor bioavailability and ... -
Novel synthetic approaches for bisnaphthalimidopropyl (BNIP) derivatives as potential anti-parasitic agents for the treatment of leishmaniasis
Keskin, Elif; Üçışık, Mehmet Hikmet; Sucu, Bilgesu Onur; Güzel, Mustafa (MDPI, 2019)Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, ... -
S-layer fusion protein as a tool functionalizing emulsomes and CurcuEmulsomes for antibody binding and targeting
Üçışık, Mehmet; Küpçü, Seda; Breitwieser, Andreas; Gelbmann, Nicola; Schuster, Bernhard; Sleytr, Uwe (Elsevier, 2015)Selective targeting of tumor cells by nanoparticle-based drug delivery systems is highly desirable because it maximizes the drug concentration at the desired target while simultaneously protecting the surrounding healthy ...