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Emulsomes meet s-layer proteins: An emerging targeted drug delivery system

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info:eu-repo/semantics/openAccess

Date

2015

Author

Üçışık, Mehmet Hikmet
Sleytr, Uwe Bernd
Schuster, Bernhard

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Citation

Üçışık, M. H., Sleytr, U. B. ve Schuster, B. (2015). Emulsomes meet s-layer proteins: An emerging targeted drug delivery system. Current Pharmaceutical Biotechnology, 16(4), 392-405. https://dx.doi.org/10.2174/138920101604150218112656

Abstract

Here, the use of emulsomes as a drug delivery system is reviewed and compared with other similar lipidic nanoformulations. In particular, we look at surface modification of emulsomes using S-layer proteins, which are self-assembling proteins that cover the surface of many prokaryotic organisms. It has been shown that covering emulsomes with a crystalline S-layer lattice can protect cells from oxidative stress and membrane damage. In the future, the capability to recrystallize S-layer fusion proteins on lipidic nanoformulations may allow the presentation of binding functions or homing protein domains to achieve highly specific targeted delivery of drug-loaded emulsomes. Besides the discussion on several designs and advantages of composite emulsomes, the success of emulsomes for the delivery of drugs to fight against viral and fungal infections, dermal therapy, cancer, and autoimmunity is summarized. Further research might lead to smart, biocompatible emulsomes, which are able to protect and reduce the side effects caused by the drug, but at the same time are equipped with specific targeting molecules to find the desired site of action.

WoS Q Kategorisi

Q3

xmlui.dri2xhtml.METS-1.0.item-scopusquality

Q1

Source

Current Pharmaceutical Biotechnology

Volume

16

Issue

4

URI

https://dx.doi.org/10.2174/138920101604150218112656
https://hdl.handle.net/20.500.12511/2274

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  • Makale Koleksiyonu [69]
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  • Scopus İndeksli Yayınlar Koleksiyonu [5815]
  • WoS İndeksli Yayınlar Koleksiyonu [5978]



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