dc.contributor.author | Kılıç, Fatma Sultan | |
dc.contributor.author | Kaygısız, Bilgin | |
dc.contributor.author | Aydın, Şule | |
dc.contributor.author | Yıldırım, Cafer | |
dc.contributor.author | Karimkhan, Hadi | |
dc.contributor.author | Öner, Setenay | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:52:12Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:52:12Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Kılıç, F., Kaygısız, B., Aydın, Ş., Yıldırım, C., Karımkhan, H. ve Öner, S. (2018). Pregabalin attenuates carrageenan induced acute inflammation in rats by inhibiting proinflammatory cytokine levels. Eurasian Journal of Medicine, 50(3) 156-159. https://dx.doi.org/10.5152/eurasianjmed.2018.17261 | en_US |
dc.identifier.issn | 1308-8734 | |
dc.identifier.issn | 1308-8742 | |
dc.identifier.uri | https://dx.doi.org/10.5152/eurasianjmed.2018.17261 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2362 | |
dc.description | WOS: 000450354500005 | en_US |
dc.description | PubMed ID: 30515034 | en_US |
dc.description.abstract | Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-alpha (TNF-alpha) and interleukine-1 beta (IL-1 beta) acting as acute phase cytokines in inflammation, and antiinflammatory cytokine IL-10, in rats. Materials and Methods: Single doses of PGB 30, 50, and 100 mg/kg and indomethacin (INDO) 5 mg/kg in the treatment groups and saline in the control group were injected once intraperitoneally prior to administration of 100 mu l of 1% CAR into the right hind paw of the rats. The paw thickness was measured using gauge calipers (Vernier calipers) before (0 hour) and every hour afterwards for 6 hours following the inflammation induction. The cytokine levels in the blood serum obtained intracardiacally were determined after 6 hours using the enzyme-linked immunosorbent assay method. p < 0.05 was considered statistically significant. Results: There was no significant difference between the 0 and 6th hour considering the paw thickness in all groups, except in the CAR group. CAR significantly increased the paw thickness at 6 hours compared to the 0 hour. All doses of PGB and INDO significantly reduced the paw thickness after 6 hours compared to the CAR group. The TNF-alpha and IL-1 beta levels in the PGB and INDO groups were comparable to the control group, whereas in the CAR group, these levels were increased. The IL-10 level was enhanced in the PGB 50 mg/kg and INDO groups. Conclusion: It was observed that all doses of PGB exerted anti-inflammatory-like effects comparable to INDO, supported by their effects on the levels of cytokines. | en_US |
dc.description.sponsorship | Scientific Research Commission of Eskisehir Osmangazi University [2015-946] | en_US |
dc.description.sponsorship | This study was supported by Scientific Research Commission of Eskisehir Osmangazi University (Project numbers: 2015-946). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | AVES | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Pregabalin | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Anti-Inflammatory Effect | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Rat | en_US |
dc.title | Pregabalin attenuates carrageenan induced acute inflammation in rats by inhibiting proinflammatory cytokine levels | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Eurasian Journal of Medicine | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-4966-1745 | en_US |
dc.identifier.volume | 50 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 156 | en_US |
dc.identifier.endpage | 159 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.5152/eurasianjmed.2018.17261 | en_US |
dc.identifier.scopusquality | Q3 | en_US |