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Toplam kayıt 18, listelenen: 1-10
The importance of computerized drug interaction checker programs used in community pharmacies to avoid potential drug interactions: A preliminary study with clarithromycin
(Istanbul Training & Research Hospital, 2019)
Introduction: Drug-drug interactions (DDI) due to multiple drug use are the most important cause of adverse drug reactions. DDIs are among medication errors that can be prevented. The integrated computerized drug interaction ...
The determine of possible drug interaction of clarithromycin
(Springer, 2016)
Phenytoin is an antiepileptic drug which is eliminated by CYP2C9, CYP2C19 (less important: CYP2C18, CYP3A4) enzyme. Therapeutic concentration range is very important due to the narrow therapeutic drug levels. Targeted ...
Prescribing pattern of PPI and clopidogrel in community pharmacies in Turkey
(Springer, 2016)
Background & Objectives: Proton Pump Inhibitors (PPIs) are among the most prescribed medications in Turkey. The use of proton pump inhibitors is one of the risk factors associated with treatment failure or unresponsiveness ...
Design and synthesis of stable N-[2-(Aryl/heteroaryl substituted)ethyl] propanamide derivatives of (S)-ketoprofen and (S)-ibuprofen as non-ulcerogenic anti-inflammatory and analgesic agents
(University of Istanbul, 2016)
The carboxylic acid groups of (S) ketoprofen and (S) ibuprofen were brought into reaction with substituted ethylamine derivatives to form (S)-2-(4-isobutylphenyl)- and (S)-2-(3-benzoylphenyl)-N-[2-(aryl/heteroaryl substituted) ...
3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: A family of antiproliferative thiazolidines
(Royal Society of Chemistry, 2015)
Cancer results from unregulated cell growth. Reactivating the process of the programmed cell death, i.e. apoptosis, is a classical anticancer therapeutic strategy. The apoptosis-inducing property of the (2RS,4R)-2-phenyl ...
Synthesis, antimicrobial activity studies and molecular property predictions of schiff bases derived from ortho-vanillin
(University of Istanbul, 2017)
Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antibacterial and antimalarial properties. At the same time, in recent years, prediction of drug-likeness, molecular, ...
Molecular modelling and activity analysis of mycobacterium tuberculosis DNA gyrase B ATPase active site
(University of Istanbul, 2017)
Computer-based algorithms and statistical techniques such as receiver operating characteristic (ROC) curves are increasingly used for the design of new ligands. X-ray crystallographic data and homology models allow examining ...
The synthesis, antimicrobial activity studies, and molecular property predictions of novel benzothiazole-2-thione derivatives
(University of Istanbul, 2017)
Benzothiazoles and 2-mercaptobenzothiazoles are important classes of bioactive organic scaffolds possessing antibacterial, antifungal, antitubercular, antiinflamma-tory, antidiabetic, and antimalarial properties. In recent ...
Molecular modelling and compound activity of the escherichia coli and staphylococcus aureus DNA gyrase B ATPase site
(University of Istanbul, 2017)
Development of new treatment ligands that can distinguish Escherichia coli (E. coli) from Staphylococcus aureus (S. aureus) is important because of bacterium multiple drug resistance. High-throughput virtual screening ...
A contraindication to metfromin therapy: Renal impairment - Adherence to prescribing guidelines at a hospital in Turkey
(University of Istanbul, 2018)
Objective: The aim of this study was to investigate whether renal functions of the patients were monitored and checked before and during metformin treatment as recommended in guidelines or whether they were disregarded and ...