The determine of possible drug interaction of clarithromycin
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CitationCeylan, C., Koçberber, E., Taner, N. ve Berk, B. (2016). The determine of possible drug interaction of clarithromycin. International Journal of Clinical Pharmacy içinde (1341-1341. ss.).
Phenytoin is an antiepileptic drug which is eliminated by CYP2C9, CYP2C19 (less important: CYP2C18, CYP3A4) enzyme. Therapeutic concentration range is very important due to the narrow therapeutic drug levels. Targeted therapeutic concentration range is 10–20 mg/L (40–80 lmol/L) in blood serum for adults and children older than 3 months. Phenytoin has highly variable pharmacokinetics due to its complex of binding to Albumin (%90). It is difﬁcult to determine the correct dosage of this drug because of signiﬁcant dose related toxicity. It is also important for inpatient in intensive care unit.