Ara
Toplam kayıt 28, listelenen: 21-28
Pancreatic tumor detection by convolutional neural networks
(Institute of Electrical and Electronics Engineers Inc., 2022)
Artificial Intelligence and its sub-branches like Machine Learning (ML) and Deep Learning (DL) applications have the potential to have positive effects that can directly affect human life. Medical imaging provides a way ...
Novel β‑hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies
(Elsevier B. V., 2022)
In this study, a series of novel β‑hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass ...
Phosphodiesterase 10A deactivation induces long-term neurological recovery, peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice
(Academic Press Inc., 2022)
The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are involved in several neuronal functions. High PDE10A ...
Functional evaluation of the tachycardia patient-derived iPSC cardiomyocytes carrying a novel pathogenic SCN5A variant
(Wiley, 2022)
Tachycardia is characterized by high beating rates that can lead to life-threatening fibrillations. Mutations in several ion-channel genes were implicated with tachycardia; however, the complex genetic contributors and ...
Stimuli-responsive theranostic system: A promising approach for augmented multimodal imaging and efficient drug release
(Elsevier B.V., 2022)
Destruction of drug resistant and invisible micro-tumors requires innovative screening and treatment modalities. Theranostic nanosystems offering multimodal imaging and therapy are attractive platforms with potential to ...
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
(Elsevier Inc., 2022)
Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ...
Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach
(Elsevier B.V., 2022)
Heart is an extensively innervated organ and its function is strictly coordinated by autonomic neural circuits. After pathological events such as myocardial infarction (MI), cardiac nerves undergo a structural and functional ...
Lamotrigine derivatives-synthesis, anti-cancer, and anti-MDR-bacterial activities
(Elsevier B.V., 2022)
A new series of quaternary ammonium salts 3–21 of lamotrigine (6-(2, 3-dichlorophenyl)-1, 2, 4-triazine-3, 5-diamine) was synthesized via N-alkylation of lamotrigine using different benzyl bromides. The new analogues were ...