dc.contributor.author | Akış, Serkan | |
dc.contributor.author | Öztürk, Uğur Kemal | |
dc.contributor.author | Keleş, Esra | |
dc.contributor.author | Alınca, Cihat Murat | |
dc.contributor.author | Kabaca, Canan | |
dc.contributor.author | Api, Murat | |
dc.date.accessioned | 2023-07-12T09:44:38Z | |
dc.date.available | 2023-07-12T09:44:38Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Akış, S., Öztürk, U. K., Keleş, E., Alınca, C. M., Kabaca, C. ve Api, M. (2023). The role of multiple high-risk human papillomavirus infections for cervical biopsies and findings in colposcopic procedures. Journal of the Turkish German Gynecology Association, 24(2), 101-108. https://dx.doi.org/10.4274/jtgga.galenos.2023.2022-8-10 | en_US |
dc.identifier.issn | 1309-0380 | |
dc.identifier.issn | 1309-0399 | |
dc.identifier.uri | https://dx.doi.org/10.4274/jtgga.galenos.2023.2022-8-10 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/11187 | |
dc.description.abstract | Objective: The clinical outcome of high-risk HPV (hr-HPV) infection varies according to genotype(s). Patients may harbor either one single hr-HPV (s-HPV) or multiple HPV (m-HPV) genotypes. Recently, the relationship between m-HPV infections and high-grade dysplasia has been investigated, and controversial results have been obtained. Therefore, the clinical significance of m-HPV is not clear. This study aimed to evaluate which group is associated with higher grade dysplasia by analyzing colposcopic punch biopsies. Material and Methods: A total of 690 patients who were scheduled for a diagnostic excisional procedure between April 2016 and January 2019 due to the detection of high-grade cervical intraepithelial neoplasia (CIN 2/3) in colposcopy were included. Patients who were not scheduled for colposcopic examination or cervical punch biopsy, or who were scheduled for an excisional procedure due to smear-biopsy incompatibility or persistent low-grade dysplasia were excluded. Patients with a negative HPV test and an unknown HPV genotype were also excluded. Results: Among the patients scheduled for excision (n=404), 74.5% had a s-HPV and 25.5% had a m-HPV infection. The proportion of CIN 1, 2 and 3 per patient in the m-HPV group was significantly higher than the s-HPV group (p=0.017). When this analysis was made for the number of CIN 2+3 per patient in the s-HPV and m-HPV groups, it was 1.29 (389/301) and 1.36 (140/103), respectively, and no difference was found (p=0.491). Conclusion: Patients in the m-HPV group, who underwent more colposcopic cervical biopsies, had higher numbers of CIN lesions, regardless of age and cytology results. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Galenos Publishing House | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Cervical Dysplasia | en_US |
dc.subject | Cervical Intraepithelial Neoplasia | en_US |
dc.subject | Colposcopy | en_US |
dc.subject | HPV | en_US |
dc.subject | Multiple HPV Infection | en_US |
dc.title | The role of multiple high-risk human papillomavirus infections for cervical biopsies and findings in colposcopic procedures | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of the Turkish German Gynecology Association | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-7069-279X | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 101 | en_US |
dc.identifier.endpage | 108 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.4274/jtgga.galenos.2023.2022-8-10 | en_US |
dc.institutionauthor | Kabaca, Canan | |
dc.identifier.wos | 001018288700005 | en_US |
dc.identifier.scopus | 2-s2.0-85162820795 | en_US |
dc.identifier.trdizinid | 1184015 | en_US |
dc.identifier.pmid | 36992075 | en_US |
dc.identifier.scopusquality | Q3 | en_US |